Publication Name	World Journal of Cardiology
Manuscript ID	26907
Country	United States

Received	2016-04-29 09:22
Peer-Review Started	2016-04-29 17:48
To Make the First Decision	2016-06-12 09:32
Return for Revision	2016-06-17 15:35
Revised	2016-07-12 11:19
Second Decision	2016-07-20 16:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-08-01 15:39
Articles in Press	2016-08-01 15:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-09-11 18:04
Publish the Manuscript Online	2016-09-20 17:21

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Novel concepts in radiation-induced cardiovascular disease
Manuscript Source	Invited Manuscript
All Author List	Jason R Cuomo, Gyanendra K Sharma, Preston D Conger and Neal L Weintraub
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health HL1126949 National Institutes of Health HL11264 National Institutes of Health HL086555
Corresponding Author	Neal L Weintraub, MD, Department of Medicine, Medical College of Georgia at Augusta University, 1459 Laney Walker Blvd., Augusta, GA 30912, United States. nweintraub@augusta.edu
Key Words	Radiotherapy; Radiation; Cardiovascular; Atherosclerosis; Cardiomyopathy; Pericarditis; Valvular; Hodgkin; Breast cancer; Radiation fibrosis
Core Tip	Radiation-induced cardiovascular disease is a common complication of mediastinal radiotherapy and often occurs years or decades after treatment. It most commonly manifests as chronic pericarditis, cardiomyopathy, and valvular or coronary heart disease. Its pathophysiology is chiefly that of radiation fibrosis, fueled by chronic states of inflammation and oxidative stress. Conventional risk factors impose additive risk to these patients and must be addressed as early as possible. Development of more sensitive imaging modalities is enabling detection at earlier stages of the disease and creating opportunities for novel treatment strategies. Percutaneous interventions have an increa-sing role in the treatment of symptomatic vascular and valvular disease.
Publish Date	2016-09-20 17:21
Citation	Cuomo JR, Sharma GK, Conger PD, Weintraub NL. Novel concepts in radiation-induced cardiovascular disease. World J Cardiol 2016; 8(9): 504-519
URL	http://www.wjgnet.com/1949-8462/full/v8/i9/504.htm
DOI	http://dx.doi.org/10.4330/wjc.v8.i9.504

Full Article (PDF)	WJC-8-504.pdf
Full Article (Word)	WJC-8-504.doc
Manuscript File	26907-Review.docx
Answering Reviewers	26907-Answering reviewers.pdf
Audio Core Tip	26907-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26907-Conflict-of-interest statement.pdf
Copyright License Agreement	26907-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	26907-Grant application form(s).pdf
Supplementary Material	Supplementary_Material_20160429055239.pptx
Peer-review Report	26907-Peer-review(s).pdf
Scientific Misconduct Check	26907-Scientific misconduct check.pdf
Scientific Editor Work List	26907-Scientific editor work list.pdf