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Publication Name World Journal of Orthopedics
Manuscript ID 27707
Country/Territory Greece
Received
2016-06-13 08:58
Peer-Review Started
2016-06-20 09:16
To Make the First Decision
2016-07-25 12:04
Return for Revision
2016-07-29 15:57
Revised
2016-08-21 17:46
Second Decision
2016-10-14 14:21
Accepted by Journal Editor-in-Chief
2016-10-17 22:42
Accepted by Company Editor-in-Chief
2016-10-27 17:19
Articles in Press
2016-10-27 17:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-12-29 13:54
Publish the Manuscript Online
2017-01-10 16:10
ISSN 2218-5836 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Orthopedics
Manuscript Type Retrospective Study
Article Title Heterotopic ossification after the use of recombinant human bone morphogenetic protein-7
Manuscript Source Invited Manuscript
All Author List Marianthi Papanagiotou, Zoe H Dailiana, Theophilos Karachalios, Sokratis Varitimidis, Michael Hantes, Georgios Dimakopoulos, Marianna Vlychou and Konstantinos N Malizos
Funding Agency and Grant Number
Funding Agency Grant Number
European Union (European Social Fund - ESF)
Greek national funds
Corresponding author Zoe H Dailiana, MD, PhD, Associate Professor, Department of Orthopaedic Surgery, Faculty of Medicine, University of Thessalia, 3 Panepistimiou St, Biopolis, 41500 Larissa, Greece. dailiana@med.uth.gr
Keywords Nonunion; Bone morphogenetic protein; Recombinant human bone morphogenetic protein-7; Heterotopic ossification; Long bone; Bone graft; Osteoinduction
Core Tip Bone morphogenetic proteins are identified as factors promoting osteogenesis. In this study an attempt was made to estimate the rate of heterotopic bone formation in patients with long bone nonunions treated with recombinant human bone morphogenetic protein-7 (rhBMP-7), and to identify predisposing factors, related to the patient, the nonunion characteristics, and the surgical procedure. Eighteen percent of the patients developed heterotopic ossification on the radiographs, without functional limitations. All patients that deve-loped heterotopic ossification were male. This rate of heterotopic ossification after rhBMP-7 use for the treatment of long bone nonunions is higher than the rates reported in literature.
Publish Date 2017-01-10 16:10
Citation Papanagiotou M, Dailiana ZH, Karachalios T, Varitimidis S, Hantes M, Dimakopoulos G, Vlychou M, Malizos KN. Heterotopic ossification after the use of recombinant human bone morphogenetic protein-7. World J Orthop 2017; 8(1): 36-41
Url http://www.wjgnet.com/2218-5836/full/v8/i1/36.htm
DOI http://dx.doi.org/10.5312/wjo.v8.i1.36
Full Article (PDF) WJO-8-36.pdf
Full Article (Word) WJO-8-36.doc
Manuscript File 27707-Review.docx
Answering Reviewers 27707-Answering reviewers.pdf
Audio Core Tip 27707-Audio core tip.mp3
Biostatistics Review Certificate 27707-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 27707-Conflict-of-interest statement.pdf
Copyright License Agreement 27707-Copyright assignment.pdf
Data Sharing Statement 27707-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 27707-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 27707-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 27707-Language certificate.pdf
Scientific Research Process 27707-Scientific research process.pdf
Peer-review Report 27707-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 27707-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 27707-Scientific misconduct check.pdf
Scientific Editor Work List 27707-Scientific editor work list.pdf