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12/19/2016 8:28:00 PM | Browse: 928 | Download: 1388
Publication Name World Journal of Gastroenterology
Manuscript ID 28068
Country/Territory India
Received
2016-06-27 14:47
Peer-Review Started
2016-06-28 10:54
To Make the First Decision
2016-08-29 09:18
Return for Revision
2016-08-29 10:12
Revised
2016-10-01 07:59
Second Decision
2016-11-08 17:21
Accepted by Journal Editor-in-Chief
2016-11-11 10:24
Accepted by Company Editor-in-Chief
2016-11-16 11:35
Articles in Press
2016-11-16 11:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-12-13 13:38
Publish the Manuscript Online
2016-12-19 20:29
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Virology
Manuscript Type Basic Study
Article Title Anti-viral role of toll like receptor 4 in hepatitis B virus infection: An in vitro study
Manuscript Source Invited Manuscript
All Author List Dipanwita Das, Neelakshi Sarkar, Isha Sengupta, Ananya Pal, Debraj Saha, Manikankana Bandopadhyay, Chandrima Das, Jimmy Narayan, Shivram Prasad Singh and Runu Chakravarty
Funding Agency and Grant Number
Funding Agency Grant Number
Indian Council of Medical Research (ICMR) intramural project
Biomolecular Assembly, Recognition and Dynamics (BARD) project 12-R &D- SIN-5.04-0103
Ramalingaswami Fellowship, Department of Biotechnology, Government of India
Corresponding Author Dr. Runu Chakravarty, ICMR Virus Unit, Kolkata, ID and BG Hospital Campus, GB 4, Kolkata 700010, India. runugc@gmail.com
Key Words Hepatitis B virus; Toll like receptor 4; Cell cycle; Epigenetic marks; Innate immune response
Core Tip The study delves into the role of toll like receptor 4 (TLR4) in hepatitis B virus (HBV) infection. Inciting TLR4 brings about drastic changes in viral and host responses in hepatocyte niche. Stimulating TLR4 represses viral replication and alters important host gene expression. Virus induced G1/S cell cycle arrest is partially released on viral elimination which is corroborated with the expression of chief cell cycle regulators. Further, we have observed activation of epigenetic signatures H3K9Ac/H3K18Ac, on viral suppression post TLR4 activation. Thus, this work is important in perspective of the role of TLR4 during HBV infection in hepatocyte microenvironment.
Publish Date 2016-12-19 20:29
Citation Das D, Sarkar N, Sengupta I, Pal A, Saha D, Bandopadhyay M, Das C, Narayan J, Singh SP, Chakravarty R. Anti-viral role of toll like receptor 4 in hepatitis B virus infection: An in vitro study. World J Gastroenterol 2016; 22(47): 10341-10352
URL http://www.wjgnet.com/1007-9327/full/v22/i47/10341.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i47.10341
Full Article (PDF) WJG-22-10341.pdf
Full Article (Word) WJG-22-10341.doc
Manuscript File 28068-Review.docx
Answering Reviewers 28068-Answering reviewers.pdf
Audio Core Tip 28068-Audio core tip.m4a
Copyright License Agreement 28068-Copyright assignment.pdf
Institutional Review Board Approval Form or Document 28068-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 28068-Language certificate.pdf
Peer-review Report 28068-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 28068-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 28068-Scientific misconduct check.pdf
Scientific Editor Work List 28068-Scientific editor work list.pdf