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11/26/2016 6:56:00 PM | Browse: 1070 | Download: 2587
Publication Name World Journal of Gastroenterology
Manuscript ID 28247
Country/Territory Italy
Received
2016-06-29 10:32
Peer-Review Started
2016-06-29 14:25
To Make the First Decision
2016-07-29 18:54
Return for Revision
2016-08-03 08:35
Revised
2016-08-12 17:45
Second Decision
2016-08-29 17:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-09-06 10:19
Articles in Press
2016-09-06 10:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-11-21 00:30
Publish the Manuscript Online
2016-11-26 18:57
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Ex vivo response to mucosal bacteria and muramyl dipeptide in inflammatory bowel disease
Manuscript Source Invited Manuscript
All Author List Claudia Loganes, Erica Valencic, Alessia Pin, Elisa Marini, Stefano Martelossi, Samuele Naviglio, Luigina De Leo, Tarcisio Not, Lorenzo Monasta, Alberto Tommasini and Annalisa Marcuzzi
Funding Agency and Grant Number
Funding Agency Grant Number
Institute for Maternal and Child Health – IRCCS “Burlo Garofolo” RC 03/09
Corresponding Author Alberto Tommasini, MD, PhD, Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”, Via dell’Istria 65/1, I-34137 Trieste, Italy. alberto.tommasini@burlo.trieste.it
Key Words Gut-microbiota; Crohn’s disease; Ulcerative colitis; Cytokines; Inflammation
Core Tip Even though previous studies have already considered cytokine secretions as marker of an inflammatory condition and mucosal imbalance in Crohn’s disease (CD) subjects, they did not take into account the autochthonous colonization of the intestinal mucosa by the disease-associated microbiota. In this work we investigated whether the microbiota can modulate the ex vivo cytokine response, in the presence or absence of antibiotics, or if a selection of cytokines could discriminate different inflammatory bowel diseases types. Through a multivariate logistic model we identified, only in specimens treated with antibiotics, a specific cytokine profile able to discriminate CD from ulcerative colitis.
Publish Date 2016-11-26 18:57
Citation Loganes C, Valencic E, Pin A, Marini E, Martelossi S, Naviglio S, De Leo L, Not T, Monasta L, Tommasini A, Marcuzzi A. Ex vivo response to mucosal bacteria and muramyl dipeptide in inflammatory bowel disease. World J Gastroenterol 2016; 22(44): 9734-9743
URL http://www.wjgnet.com/1007-9327/full/v22/i44/9734.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i44.9734
Full Article (PDF) WJG-22-9734.pdf
Full Article (Word) WJG-22-9734.doc
Manuscript File 28247-Review.docx
Answering Reviewers 28247-Answering reviewers.pdf
Audio Core Tip 28247-Audio core tip.mp3
Biostatistics Review Certificate 28247-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 28247-Conflict-of-interest statement.pdf
Copyright License Agreement 28247-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 28247-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160628114906.pdf
Institutional Animal Care and Use Committee Approval Form or Document 28247-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 28247-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 28247-Language certificate.pdf
Supplementary Material 28247-Supplementary material.docx
Peer-review Report 28247-Peer-review(s).pdf
Scientific Misconduct Check 28247-Scientific misconduct check.pdf
Scientific Editor Work List 28427-Scientific editor work list.pdf