Publication Name	World Journal of Gastroenterology
Manuscript ID	28276
Country	Hungary

Received	2016-06-29 11:45
Peer-Review Started	2016-06-29 13:22
To Make the First Decision	2016-08-08 13:34
Return for Revision	2016-08-12 11:13
Revised	2016-08-26 02:16
Second Decision	2016-09-21 15:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-09-28 17:52
Articles in Press	2016-09-28 17:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-10-27 15:28
Publish the Manuscript Online	2016-11-06 15:43

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Presepsin teardown - pitfalls of biomarkers in the diagnosis and prognosis of bacterial infection in cirrhosis
Manuscript Source	Invited Manuscript
All Author List	Maria Papp, Tamas Tornai, Zsuzsanna Vitalis, Istvan Tornai, David Tornai, Tamas Dinya, Andrea Sumegi and Peter Antal-Szalmas
Funding Agency and Grant Number	Funding Agency Grant Number János Bólyai Research Scholarship of Hungarian Academy of Sciences BO/00426/11 University of Debrecen and Research Grant of National Research RH/885/2013 Development and Innovation Office K115818/2015/1
Corresponding Author	Maria Papp, MD, PhD, Department of Internal Medicine, Division of Gastroenterology, University of Debrecen, Faculty of Medicine, Nagyerdei krt. 98, H-4032 Debrecen, Hungary. papp.maria@med.unideb.hu
Key Words	Presepsin; Cirrhosis; Bacterial infection; Organ failure; Mortality
Core Tip	C-reactive protein (CRP) and procalcitonin (PCT) are broadly used in clinical practice to aid early diagnosis of bacterial infections, but they have limitations in cirrhosis. Additional biomarkers with enhanced accuracy are highly needed. Presepsin is a novel biomarker of infection and sepsis, but has not been assessed in cirrhosis so far. In the present study we evaluated the diagnostic and prognostic performance of presepsin in cirrhosis-associated infections in comparison with classic acute phase proteins. Presepsin measurement enhanced diagnostic utility of CRP and reflected the severity of infections more accurately, with a similar efficacy as PCT. Advanced disease stage and renal failure limited the diagnostic accuracy. The increase in PCT level but not in presepsin concentration was an independent predictor of short-term mortality during infectious episodes.
Publish Date	2016-11-06 15:43
Citation	Papp M, Tornai T, Vitalis Z, Tornai I, Tornai D, Dinya T, Sumegi A, Antal-Szalmas P. Presepsin teardown - pitfalls of biomarkers in the diagnosis and prognosis of bacterial infection in cirrhosis. World J Gastroenterol 2016; 22(41): 9172-9185
URL	http://www.wjgnet.com/1007-9327/full/v22/i41/9172.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i41.9172

Full Article (PDF)	WJG-22-9172.pdf
Full Article (Word)	WJG-22-9172.doc
Manuscript File	28276-Review.docx
Answering Reviewers	28276-Answering reviewers.pdf
Audio Core Tip	28276-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	28276-Conflict-of-interest statement.pdf
Copyright License Agreement	28276-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	28276-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	28276-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	28276-Language certificate.pdf
Peer-review Report	28276-Peer-review(s).pdf
Scientific Misconduct Check	28276-Scientific misconduct check.pdf
Scientific Editor Work List	28276-Scientific editor work list.pdf