Publication Name	World Journal of Gastroenterology
Manuscript ID	28841
Country	Greece

Received	2016-07-18 08:19
Peer-Review Started	2016-07-21 08:30
To Make the First Decision	2016-08-29 09:18
Return for Revision	2016-08-29 09:57
Revised	2016-08-31 23:09
Second Decision	2016-09-21 17:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-09-28 19:23
Articles in Press	2016-09-28 19:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-10-28 13:58
Publish the Manuscript Online	2016-11-06 15:43

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Emerging role of obeticholic acid in the management of nonalcoholic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Evangelia Makri, Evangelos Cholongitas and Konstantinos Tziomalos
Funding Agency and Grant Number
Corresponding Author	Evangelos Cholongitas, MD, PhD, Assistant Professor of Internal Medicine, Fourth Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, 49 Konstantinoupoleos street, 54642 Thessaloniki, Greece. cholongitas@yahoo.gr
Key Words	Nonalcoholic fatty liver disease; Obeticholic acid; Farnesoid X receptors; Insulin resistance; Fibrosis; Dyslipidemia; Steatosis; Hepatocellular cancer
Core Tip	Nonalcoholic fatty liver disease (NAFLD) is the commonest chronic liver disease in Western coun-tries, can progress to cirrhosis and is associated with increased all-cause and cardiovascular disease mortality risk. Current pharmacological treatment of NAFLD has limited efficacy and therefore, there is a pressing need to develop more effective and safe agents for this common and life-threatening disease. Obeticholic acid (OCA), a selective agonist of the farnesoid X receptors, might be a useful agent in the management of NAFLD. In the Farnesoid X Receptor Ligand Obeticholic Acid in non-alcoholic steatohepatitis (NASH) Treatment (FLINT) trial in patients with NASH, OCA administration was associated with improvements in liver histology, while weight loss and reduction in blood pressure were also observed. Although its adverse effects on the lipid profile and insulin sensitivity are worrisome, given the increased cardiovascular risk of this population, OCA might be considered in selected patients with NAFLD/NASH, particularly in those with adequately controlled glucose and lipid levels.
Publish Date	2016-11-06 15:43
Citation	Makri E, Cholongitas E, Tziomalos K. Emerging role of obeticholic acid in the management of nonalcoholic fatty liver disease. World J Gastroenterol 2016; 22(41): 9039-9043
URL	http://www.wjgnet.com/1007-9327/full/v22/i41/9039.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i41.9039

Full Article (PDF)	WJG-22-9039.pdf
Full Article (Word)	WJG-22-9039.doc
Manuscript File	28841-Review.docx
Answering Reviewers	28841-Answering reviewers.pdf
Audio Core Tip	28841-Audio core tip.wma
Conflict-of-Interest Disclosure Form	28841-Conflict-of-interest statement.pdf
Copyright License Agreement	28841-Copyright assignment.pdf
Peer-review Report	28841-Peer-review(s).pdf
Scientific Misconduct Check	28841-Scientific misconduct check.pdf
Scientific Editor Work List	28841-Scientific editor work list.pdf