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11/6/2016 3:43:00 PM | Browse: 693 | Download: 1062
Publication Name World Journal of Gastroenterology
Manuscript ID 29207
Country/Territory Italy
Received
2016-08-02 09:33
Peer-Review Started
2016-08-03 11:23
To Make the First Decision
2016-08-22 14:27
Return for Revision
2016-08-24 19:08
Revised
2016-09-09 00:16
Second Decision
2016-09-21 15:02
Accepted by Journal Editor-in-Chief
2016-09-21 15:38
Accepted by Company Editor-in-Chief
2016-10-19 17:11
Articles in Press
2016-10-19 17:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-10-31 09:15
Publish the Manuscript Online
2016-11-06 15:43
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Mesenchymal stromal cell-based therapy: Regulatory and translational aspects in gastroenterology
Manuscript Source Invited Manuscript
All Author List Giovanni Dothel, Emanuel Raschi, Roberto Rimondini and Fabrizio De Ponti
Funding Agency and Grant Number
Corresponding Author Fabrizio De Ponti, MD, PhD, Pharmacology Unit, Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Via Irnerio, 48, I-40126 Bologna, Italy. fabrizio.deponti@unibo.it
Key Words Mesenchymal stromal cells; Mesenchymal stem cells; Inflammatory bowel diseases; Intestinal disorders; Translational medicine
Core Tip mesenchymal stromal cells (MSCs) release immunomodulatory mediators upon inflammatory stimuli. This behavior is attractive for the development of advanced therapeutic strategies applied to several intestinal disorders where inflammation is a key pathophysiological feature. In order to assess quality, efficacy and safety of MSC-based therapy, a novel approach to pharmacokinetics/pharmacodynamics (PK/PD) is mandatory. This must rely on careful assessment of cell phenotype, signaling and homing mechanisms. In this regard, experimental models must take advantage of the most updated knowledge in order to reflect the PK/PD mechanisms in humans. Finally, an alternative approach to the “whole-cell treatment” applies MSC-derived mediators alone in order to avoid the hypothesized serious adverse events deriving from a biological entity mostly acting systemically.
Publish Date 2016-11-06 15:43
Citation Dothel G, Raschi E, Rimondini R, De Ponti F. Mesenchymal stromal cell-based therapy: Regulatory and translational aspects in gastroenterology. World J Gastroenterol 2016; 22(41): 9057-9068
URL http://www.wjgnet.com/1007-9327/full/v22/i41/9057.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i41.9057
Full Article (PDF) WJG-22-9057.pdf
Full Article (Word) WJG-22-9057.doc
Manuscript File 29207-Review.docx
Answering Reviewers 29207-Answering reviewers.pdf
Audio Core Tip 29207-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 29207-Conflict-of-interest statement.pdf
Copyright License Agreement 29207-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 29207-Language certificate.pdf
Peer-review Report 29207-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 29207-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 29207-Scientific misconduct check.pdf
Scientific Editor Work List 29207-Scientific editor work list.pdf