Publication Name	World Journal of Gastroenterology
Manuscript ID	29484
Country	United States

Received	2016-08-16 15:55
Peer-Review Started	2016-08-17 15:14
To Make the First Decision	2016-09-20 10:50
Return for Revision	2016-09-20 13:59
Revised	2016-10-12 11:52
Second Decision	2016-11-08 17:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-11-16 11:39
Articles in Press	2016-11-16 11:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-11 13:31
Publish the Manuscript Online	2016-12-13 00:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Sirtuins and nonalcoholic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Fatiha Nassir and Jamal A Ibdah
Funding Agency and Grant Number
Corresponding Author	Jamal A Ibdah, MD, PhD, Professor, Director, Department of Medicine, Division of Gastroenterology and Hepatology, University of Missouri, 1 Hospital Drive, DC043.00, CE405, Columbia, MO 65212, United States. ibdahj@health.missouri.edu
Key Words	SIRT1; SIRT3; Sirtuins; Non-alcoholic fatty liver disease
Core Tip	Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease with no effective pharmacological therapy. The discovery of treatment is hindered by the insufficient understanding of the pathophysiology of the disease. Sirtuins are key players in hepatic carbohydrate and lipid metabolism, insulin signaling, and inflammation and hence may represent a novel therapeutic target for NAFLD. However, the particular role for each sirtuin, the cross talk between sirtuins in different cell compartments or within a given organelle, and the development of selective sirtuins activators/inhibitors still need further investigation.
Publish Date	2016-12-13 00:40
Citation	Nassir F, Ibdah JA. Sirtuins and nonalcoholic fatty liver disease. World J Gastroenterol 2016; 22(46): 10084-10092
URL	http://www.wjgnet.com/1007-9327/full/v22/i46/10084.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i46.10084

Full Article (PDF)	WJG-22-10084.pdf
Full Article (Word)	WJG-22-10084.doc
Manuscript File	29484-Review.docx
Answering Reviewers	29484-Answering reviewers.pdf
Audio Core Tip	29484-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	29484-Conflict-of-interest statement.pdf
Copyright License Agreement	29484-Copyright assignment.pdf
Peer-review Report	29484-Peer-review(s).pdf
Scientific Misconduct Check	29484-Scientific misconduct check.pdf
Scientific Editor Work List	29484-Scientific editor work list.pdf