| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Molecular mechanisms of apoptosis in hepatocellular carcinoma cells induced by ethanol extracts of Solanum lyratum Thumb through the mitochondrial pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Qiang Mo, Hong-Yu Wei, Gan-Rong Huang, Ling-Yuan Xu, Yu-Li Chen, Jiang Qi, Wei Xian, Yan-Chun Qin, Lian-Deng Wei, Li-Juan Zhao, Yan-Qiang Huang, Wei Xing, Hong-Qin Pu, Peng-Ya Wei, Chao-Gan Li and Qiu-Chun Liang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guangxi Key Disciplines (Pathogen Biology) [2013] 16, Key Laboratory Cultivation Base of Universities in Guangxi (Guangxi Education Research [2014] 6) |
|
| Science and Technology Research Projects of Universities in Guangxi in 2014 |
YB2014307 |
| Guangxi Natural Science Fund Project |
2013GXNSFAA019249 |
| Scientific Research Project of The Department of Education of Guangxi Zhuang Autonomous Region |
200810LX327 |
| Guangxi Natural Science Fund Project |
2014GXNSFBA118148 |
|
| Corresponding Author |
Dr. Yan-Qiang Huang, Professor, Breeding Base of Microbial Infection Key Laboratory in the West Guangxi, Youjiang Medical University for Nationalities, No. 98 Countryside Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. hyq77615@163.com |
| Key Words |
Solanum lyratum Thumb; Hepatocellular carcinoma cell; Cell apoptosis; Mitochondrial pathway; Molecular mechanism |
| Core Tip |
Chinese herbal medicine has a very good effect on the tumor. Solanum lyratum Thumb (ST) belonging to Solanaceae, is generally used to treat tumors, so it is a commonly used anticancer drug. However, the effects and mechanism of ST on tumor cells are unclear. This experiment verified that ST can induce the apoptosis of hepatocellular carcinoma SMMC-7721 cells; moreover, the apoptosis mechanism was related to the expression of Fas, FasL, caspase-8, caspase-3, p53 and Bcl-2 in the mitochondrial pathway. This result provides powerful evidence of the improved apoptosis effects of ST on hepatocellular carcinoma cells. |
| Publish Date |
2017-02-12 17:23 |
| Citation |
Mo XQ, Wei HY, Huang GR, Xu LY, Chen YL, Qi J, Xian W, Qin YC, Wei LD, Zhao LJ, Huang YQ, Xing W, Pu HQ, Wei PY, Li CG, Liang QC. Molecular mechanisms of apoptosis in hepatocellular carcinoma cells induced by ethanol extracts of Solanum lyratum Thumb through the mitochondrial pathway. World J Gastroenterol 2017; 23(6): 1010-1017 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i6/1010.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i6.1010 |
