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Articles Published Processes
4/17/2017 7:22:19 PM | Browse: 1231 | Download: 2141
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Received |
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2016-10-13 09:32 |
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Peer-Review Started |
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2016-10-17 11:41 |
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To Make the First Decision |
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2016-12-14 08:42 |
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Return for Revision |
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2016-12-15 11:16 |
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Revised |
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2017-01-10 09:00 |
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Second Decision |
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2017-01-22 16:43 |
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Accepted by Journal Editor-in-Chief |
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2017-01-23 00:27 |
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Accepted by Company Editor-in-Chief |
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2017-02-13 13:35 |
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Articles in Press |
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2017-02-13 13:36 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-04-10 20:57 |
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Publish the Manuscript Online |
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2017-04-17 19:22 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Max J Friedrich, Matthias D Wimmer, Jan Schmolders, Andreas C Strauss, Milena M Ploger, Hendrik Kohlhof, Dieter C Wirtz, Sascha Gravius and Thomas M Randau |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Deutsche Arthrose-Hilfe e.V. |
P192-A362-2009-12 |
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| Corresponding Author |
Thomas M Randau, MD, Department of Orthopedics and Trauma Surgery, University Clinic of Bonn, Sigmund Freud Str. 25, 53125 Bonn, Germany. thomas.randau@ukbonn.de |
| Key Words |
Aseptic loosening; Diagnostic; RANK-ligand; Periprosthetic joint infection; Biomarker; Osteoprotegerin |
| Core Tip |
No statistically significant differences in the serum concentration of RANK-ligand (RANKL) and osteoprotegerin (OPG) were found between aseptic loosening and periprosthetic joint infection (PJI) with a certain trend of lower concentrations in the PJI group. Nevertheless, a RANKL/OPG ratio > 60 ruled out PJI in all cases. In the differentiation between a stable and loose implant the parameters measured showed no significant difference, which let to the conclusion that the sole use of these parameters for differentiating PJI and aseptic loosening cannot be recommended. RANK and OPG may have utility as a conformation test but are not an effective screening parameter for the discrimination of PJI and AL. |
| Publish Date |
2017-04-17 19:22 |
| Citation |
Friedrich MJ, Wimmer MD, Schmolders J, Strauss AC, Ploger MM, Kohlhof H, Wirtz DC, Gravius S, Randau TM. RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening. World J Orthop 2017; 8(4): 342-349 |
| URL |
http://www.wjgnet.com/2218-5836/full/v8/i4/342.htm |
| DOI |
http://dx.doi.org/10.5312/wjo.v8.i4.342 |
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