Publication Name	World Journal of Gastroenterology
Manuscript ID	30766
Country	Italy

Received	2016-10-16 08:35
Peer-Review Started	2016-10-31 17:10
To Make the First Decision	2016-12-19 09:50
Return for Revision	2016-12-20 21:30
Revised	2016-12-29 08:09
Second Decision	2017-01-16 11:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-01-18 16:18
Articles in Press	2017-01-18 16:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-07 14:58
Publish the Manuscript Online	2017-02-20 17:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Subclinical atherosclerosis is linked to small intestinal bacterial overgrowth via vitamin K2-dependent mechanisms
Manuscript Source	Invited Conference Manuscripts
All Author List	Francesca Romana Ponziani, Maurizio Pompili, Enrico Di Stasio, Maria Assunta Zocco, Antonio Gasbarrini and Roberto Flore
Funding Agency and Grant Number
Corresponding Author	Francesca Romana Ponziani, MD, Internal Medicine, Gastroenterology and Hepatology, Agostino Gemelli Hospital, Largo Agostino Gemelli 8, 00168 Rome, Italy. francesca.ponziani@yahoo.it
Key Words	small intestinal bacterial overgrowth; vitamin K; dysbiosis; atherosclerosis; cardiovascular disease risk
Core Tip	The matrix Gla-protein is involved in maintaining vascular health and vitamin K2 is a prerequisite for its activation and function. Intestinal bacteria are the main source of vitamin K2 in humans and small intestinal bacterial overgrowth (SIBO) is associated with altered vitamin K2 metabolism. This study demonstrates that SIBO is associated with increased plasma levels of inactive matrix Gla-protein, which, in turn, correlates directly with early markers of atherosclerotic disease such as increased arterial stiffness. Therefore, SIBO has the potential to serve as an indicator for increased risk of developing an overt cardiovascular disease.
Publish Date	2017-02-20 17:58
Citation	Ponziani FR, Pompili M, Di Stasio E, Zocco MA, Gasbarrini A, Flore R. Subclinical atherosclerosis is linked to small intestinal bacterial overgrowth via vitamin K2-dependent mechanisms. World J Gastroenterol 2017; 23(7): 1241-1249
URL	http://www.wjgnet.com/1007-9327/full/v23/i7/1241.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i7.1241

Full Article (PDF)	WJG-23-1241.pdf
Full Article (Word)	WJG-23-1241.doc
Manuscript File	30766-Review.docx
Answering Reviewers	30766-Aswering reviewers.pdf
Audio Core Tip	30766-Audio core tip.mp3
Biostatistics Review Certificate	30766-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	30766-Conflict-of-interest statement.pdf
Copyright License Agreement	30766-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	30766-Institutional review board statement.pdf
Supplementary Material	30766-Supplementary material.pdf
Peer-review Report	30766-Peer-review(s).pdf
Scientific Misconduct Check	30766-Scientific misconduct check.pdf
Scientific Editor Work List	30766-Scientific editor work list.pdf