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6/22/2017 11:06:41 AM | Browse: 794 | Download: 679
Publication Name World Journal of Psychiatry
Manuscript ID 31280
Country/Territory United Kingdom
Received
2016-11-08 10:03
Peer-Review Started
2016-11-10 11:23
To Make the First Decision
2017-01-14 10:37
Return for Revision
2017-01-20 17:46
Revised
2017-01-25 23:06
Second Decision
2017-04-10 17:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-04-20 08:37
Articles in Press
2017-04-20 08:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-06-06 06:52
Publish the Manuscript Online
2017-06-22 11:06
ISSN 2220-3206 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Psychiatry
Manuscript Type Review
Article Title Understanding the pathophysiology of postpartum psychosis: Challenges and new approaches
Manuscript Source Invited Manuscript
All Author List William Davies
Funding Agency and Grant Number
Funding Agency Grant Number
Medical Research Council Centre for Neuropsychiatri Genetics and Genomics MR/L010305/1
Corresponding Author Dr. William Davies, School of Psychology, Cardiff University, Tower Building 70, Park Place, Cardiff CF10 3AT, United Kingdom. daviesw4@cardiff.ac.uk
Key Words CCN3; Immune system; Steroid sulfatase; Nephroblastoma-overexpressed; Mouse; Animal model; Risk factor
Core Tip Postpartum psychosis is a severe psychiatric condition affecting a small proportion of women shortly after childbirth. The pathophysiological mechanisms underlying risk for the condition are extremely poorly-defined, but may include perturbed immune function, altered tryptophan metabolism and serotonergic dysfunction. Here, I critically review evidence underlying these assumptions, and discuss a novel model for postpartum psychosis risk, involving maternal deficiency for the enzyme steroid sulfatase, and overexpression of the CCN gene family, based upon emerging data from a recently-developed mouse animal model. Identifying and characterising predictive biomarkers for postpartum psychosis risk will help to ensure prompt clinical inter­vention if required.
Publish Date 2017-06-22 11:06
Citation Davies W. Understanding the pathophysiology of postpartum psychosis: Challenges and new approaches. World J Psychiatr 2017; 7(2): 77-88
URL http://www.wjgnet.com/2220-3206/full/v7/i2/77.htm
DOI http://dx.doi.org/10.5498/wjp.v7.i2.77
Full Article (PDF) WJP-7-77.pdf
Full Article (Word) WJP-7-77.doc
Manuscript File 31280-Review.docx
Answering Reviewers 31280-Answering reviewers.pdf
Audio Core Tip 31280-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 31280-Conflict-of-interest statement.pdf
Copyright License Agreement 31280-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 31280-Grant application form(s).pdf
Peer-review Report 31280-Peer-review(s).pdf
Scientific Misconduct Check 31280-Scientific misconduct check.pdf
Scientific Editor Work List 31280-Scientific editor work list.pdf