| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Takuhito Sezaki, Yuki Hirata, Teruki Hagiwara, Yuki I Kawamura, Tadashi Okamura, Rieko Takanashi, Kenta Nakano, Miwa Tamura-Nakano, Linda C Burkly and Taeko Dohi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Education, Culture, Sports, Science, and Technology |
[B] 5H04503 |
| Ministry of Education, Culture, Sports, Science, and Technology |
[C] 25460965 |
| National Center for Global Health and Medicine |
23-101 |
| National Center for Global Health and Medicine |
25-104 |
| National Center for Global Health and Medicine |
26-110 |
| National Center for Global Health and Medicine |
26-117 |
| National Center for Global Health and Medicine |
27-1406 |
| MEXT-Supported Program for the Strategic Research Foundation at Private Universities |
|
| Ministry of Education, Culture, Sports, Science, and Technology |
16K09299 |
|
| Corresponding Author |
Dr. Taeko Dohi, Director, Department of Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba 272-8516, Japan. dohi@ri.ncgm.go.jp |
| Key Words |
Cancer chemotherapy; Interleukin-13; Interleukin-33; Interleukin-13 receptor α2 |
| Core Tip |
IL-13 signaling via IL-13 receptor (IL-13R)α1 plays a central role in developing diarrhea, a major side effect of 5-fluorouracil (5-FU). Disruption of the TWEAK/Fn14 pathway alleviated diarrhea by downregulating expression of IL-13 and upregulating expression of IL-13Rα2, a decoy IL-13 receptor. The IL-13Rα2 was induced by IL-33 in mesenchymal cells of 5-FU-treated intestines in vivo and fibroblasts in vitro. IL-33 expression was independent of TWEAK/Fn14 signaling, and its cell protective function in 5-FU-treated mice was enhanced in the absence of Fn14. Disruption of the TWEAK/Fn14 pathway affects several interconnected pathways to attenuate 5-FU-induced intestinal side effects. |
| Publish Date |
2017-04-06 18:30 |
| Citation |
Sezaki T, Hirata Y, Hagiwara T, Kawamura YI, Okamura T, Takanashi R, Nakano K, Tamura-Nakano M, Burkly LC, Dohi T. Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice. World J Gastroenterol 2017; 23(13): 2294-2307 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i13/2294.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i13.2294 |
