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7/12/2017 6:45:23 AM | Browse: 1042 | Download: 1754
Publication Name World Journal of Gastroenterology
Manuscript ID 31906
Country/Territory Finland
Received
2016-12-14 09:30
Peer-Review Started
2016-12-16 19:00
To Make the First Decision
2017-02-23 09:56
Return for Revision
2017-02-27 16:30
Revised
2017-03-14 00:33
Second Decision
2017-05-15 02:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-05-19 08:27
Articles in Press
2017-05-19 08:27
Publication Fee Transferred
2017-06-06 16:36
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-07-03 05:49
Publish the Manuscript Online
2017-07-12 06:45
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Prospective Study
Article Title Divergent expression of bacterial wall sensing toll-like receptors 2 and 4 in colorectal cancer
Manuscript Source Unsolicited Manuscript
All Author List Karoliina Paarnio, Sara Väyrynen, Kai Klintrup, Pasi Ohtonen, Markus J Mäkinen, Jyrki Mäkelä and Tuomo J Karttunen
Funding Agency and Grant Number
Funding Agency Grant Number
Mary and Georg C Ehrnrooths Foundation
Corresponding Author Karoliina Paarnio, MD, Research Unit of Surgery, Anesthesia and Intensive Care, University of Oulu, POB 5000, 90014 Oulu, Finland. karoliina.paarnio@me.com
Key Words Colorectal Cancer; Toll-like receptor 2; Toll-like receptor 4; Inflammation; Prognosis
Core Tip toll-like receptor 4 (TLR4) is downregulated in colorectal cancer (CRC), suggesting a role as a tumour suppressor. Low expression of TLR4 in the invasive front marks poor prognosis and is associated with metastatic disease. The most significant finding was the association between weak TLR4 expression in the tumour front and 36.9% (p = 0.044) lower cancer-specific survival in cancer of the proximal colon as compared with strong TLR4 expression. Weak TLR4 staining in tumour front was present in 50% (11/22) of the cases with metastases and only in 17% (16/94) of those without metastases (p = 0.001). TLR2 is upregulated in CRC but not associated with prognosis.
Publish Date 2017-07-12 06:45
Citation Paarnio K, Väyrynen S, Klintrup K, Ohtonen P, Mäkinen MJ, Mäkelä J, Karttunen TJ. Divergent expression of bacterial wall sensing toll-like receptors 2 and 4 in colorectal cancer. World J Gastroenterol 2017; 23(26): 4831-4838
URL http://www.wjgnet.com/1007-9327/full/v23/i26/4831.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i26.4831
Full Article (PDF) WJG-23-4831.pdf
Full Article (Word) WJG-23-4831.doc
Manuscript File 31906-Review.docx
Answering Reviewers 31906-Answering reviewers.pdf
Audio Core Tip 31906-Audio core tip.mp3
Biostatistics Review Certificate 31906-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 31906-Conflict-of-interest statement.pdf
Copyright License Agreement 31906-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 31906-Grant application form(s).PDF
Signed Informed Consent Form(s) or Document(s) 31906-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 31906-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 31906-Language certificate.pdf
Peer-review Report 31906-Peer-review(s).pdf
Scientific Misconduct Check 31906-Scientific misconduct check.pdf
Scientific Editor Work List 31906-Scientific editor work list.pdf