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Articles Published Processes
7/12/2017 6:45:23 AM | Browse: 1164 | Download: 2182
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Received |
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2016-12-14 09:30 |
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Peer-Review Started |
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2016-12-16 19:00 |
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To Make the First Decision |
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2017-02-23 09:56 |
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Return for Revision |
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2017-02-27 16:30 |
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Revised |
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2017-03-14 00:33 |
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Second Decision |
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2017-05-15 02:53 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-05-19 08:27 |
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Articles in Press |
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2017-05-19 08:27 |
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Publication Fee Transferred |
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2017-06-06 16:36 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-07-03 05:49 |
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Publish the Manuscript Online |
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2017-07-12 06:45 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Divergent expression of bacterial wall sensing toll-like receptors 2 and 4 in colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Karoliina Paarnio, Sara Väyrynen, Kai Klintrup, Pasi Ohtonen, Markus J Mäkinen, Jyrki Mäkelä and Tuomo J Karttunen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Mary and Georg C Ehrnrooths Foundation |
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| Corresponding Author |
Karoliina Paarnio, MD, Research Unit of Surgery, Anesthesia and Intensive Care, University of Oulu, POB 5000, 90014 Oulu, Finland. karoliina.paarnio@me.com |
| Key Words |
Colorectal Cancer; Toll-like receptor 2; Toll-like receptor 4; Inflammation; Prognosis |
| Core Tip |
toll-like receptor 4 (TLR4) is downregulated in colorectal cancer (CRC), suggesting a role as a tumour suppressor. Low expression of TLR4 in the invasive front marks poor prognosis and is associated with metastatic disease. The most significant finding was the association between weak TLR4 expression in the tumour front and 36.9% (p = 0.044) lower cancer-specific survival in cancer of the proximal colon as compared with strong TLR4 expression. Weak TLR4 staining in tumour front was present in 50% (11/22) of the cases with metastases and only in 17% (16/94) of those without metastases (p = 0.001). TLR2 is upregulated in CRC but not associated with prognosis. |
| Publish Date |
2017-07-12 06:45 |
| Citation |
Paarnio K, Väyrynen S, Klintrup K, Ohtonen P, Mäkinen MJ, Mäkelä J, Karttunen TJ. Divergent expression of bacterial wall sensing toll-like receptors 2 and 4 in colorectal cancer. World J Gastroenterol 2017; 23(26): 4831-4838 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i26/4831.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i26.4831 |
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