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8/7/2017 9:17:02 AM | Browse: 639 | Download: 727
Publication Name World Journal of Gastroenterology
Manuscript ID 32585
Country/Territory China
2017-01-16 08:28
Peer-Review Started
2017-01-16 14:17
To Make the First Decision
2017-02-09 13:18
Return for Revision
2017-02-14 10:53
2017-02-25 14:22
Second Decision
2017-03-03 16:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-03-06 17:01
Articles in Press
2017-03-06 17:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-07-14 03:17
Typeset the Manuscript
2017-07-27 11:06
Publish the Manuscript Online
2017-08-07 09:17
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which selected by an inhouse editor and fully peer-reviewed by external reviewers. It distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Clinical Trials Study
Article Title Phase Ⅰ clinical study of personalized peptide vaccination combined with radiotherapy for advanced hepatocellular carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Jie Shen, Li-Feng Wang, Zheng-Yun Zou, Wei-Wei Kong, Jing Yan, Fan-Yan Meng, Fang-Jun Chen, Juan Du, Jie Shao, Qiu-Ping Xu, Hao-Zhen Ren, Ru-Tian Li, Jia Wei, Xiao-Ping Qian and Bao-Rui Liu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81401969
Jiangsu Provincial Medical Youth Talent QNRC2016043
the Key Medical Science and Technology Development Project of Nanjing ZKX16032
Corresponding Author Bao-Rui Liu, MD, PhD, Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University, Clinical Cancer Institute of Nanjing University, 321 Zhongshan Rd, Nanjing 210008, Jiangsu Province, China. baoruiliu@nju.edu.cn
Key Words Personalized peptide vaccination; TOMO radiotherapy; Cytotoxic lymphocytes; Hepatocellular carcinoma
Core Tip Advanced hepatocellular carcinoma (HCC) is a challenging disease to treat because of its advanced stage at diagnosis and rapid progression. We developed a new treatment modality, cellular immune therapy based on personalized peptide vaccination combined with radiotherapy, to treat advanced HCC. It integrates personalized peptide vaccination in tumor immunotherapy, takes full advantages of the immune modulation of radiotherapy, promotes tumor cells to release antigens and results in a more effective therapeutic strategy with regard to local and systemic control.
Publish Date 2017-08-07 09:17
Citation Shen J, Wang LF, Zou ZY, Kong WW, Yan J, Meng FY, Chen FJ, Du J, Shao J, Xu QP, Ren HZ, Li RT, Wei J, Qian XP, Liu BR. Phase Ⅰ clinical study of personalized peptide vaccination combined with radiotherapy for advanced hepatocellular carcinoma. World J Gastroenterol 2017; 23(29): 5395-5404
URL http://www.wjgnet.com/1007-9327/full/v23/i29/5395.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i29.5395
Full Article (PDF) WJG-23-5395.pdf
Full Article (Word) WJG-23-5395.doc
Manuscript File 32585-Review.docx
Answering Reviewers 32585-Answering reviewers.pdf
Audio Core Tip 32585-Audio core tip.m4a
Biostatistics Review Certificate 32585-Biostatistics statement.pdf
Clinical Trial Registration Statement 32585-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 32585-Conflict-of-interest statement.pdf
Copyright License Agreement 32585-Copyright assignment.pdf
Data Sharing Statement 32585-Data sharing statement.pdf
Signed Informed Consent Form(s) or Document(s) 32585-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document 32585-Institutional review board statement.pdf
Peer-review Report 32585-Peer-review(s).pdf
Scientific Misconduct Check 32585-Scientific misconduct check.pdf
Scientific Editor Work List 32585-Scientific editor work list.pdf