Publication Name	World Journal of Clinical Oncology
Manuscript ID	32703
Country	Italy

Received	2017-01-20 10:04
Peer-Review Started	2017-01-20 16:49
To Make the First Decision	2017-03-27 08:23
Return for Revision	2017-03-29 10:59
Revised	2017-04-05 18:08
Second Decision	2017-04-29 15:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-05-05 18:21
Articles in Press	2017-05-05 18:21
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-05-08 18:46
Typeset the Manuscript	2017-05-26 04:56
Publish the Manuscript Online	2017-06-02 05:29

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Review
Article Title	Multidisciplinary approach of colorectal cancer liver metastases
Manuscript Source	Invited Manuscript
All Author List	Giammaria Fiorentini, Donatella Sarti, Camillo Aliberti, Riccardo Carandina, Andrea Mambrini and Stefano Guadagni
Funding Agency and Grant Number
Corresponding Author	Dr. Giammaria Fiorentini, Onco-Ematology Department, Azienda Ospedaliera “Ospedali Riuniti Marche Nord”, Via Lombroso 1, 61122 Pesaro, Italy. g.fiorentini@alice.it
Key Words	Colorectal cancer; Chemoembolization; Liver metastases; Hepatic resection; Colorectal cancer liver metastases; Chemotherapy; Arterial infusion chemotherapy; Radioembolization
Core Tip	Improvements of colorectal cancer liver metastases (CRC-LM) treatment allows the down-staging of several patients. There is currently no agreement in the correct sequence of surgical resection of the primary cancer and metastatic disease. Surgical resection can be performed if the complete removal of cancer is achievable, leaving an adequate normal liver tissue. Neoadjuvant chemotherapy is widely accepted as primary therapy. Chemotherapy may lead to disease regression for unresectable CRC-LM, allowing resection and cure. The application of loco-regional therapies is increasing. They are recommended as third-line treatment for unresectable CRC-LM and have a palliative intent.
Publish Date	2017-06-02 05:29
Citation	Fiorentini G, Sarti D, Aliberti C, Carandina R, Mambrini A, Guadagni S. Multidisciplinary approach of colorectal cancer liver metastases. World J Clin Oncol 2017; 8(3): 190-202
URL	http://www.wjgnet.com/2218-4333/full/v8/i3/190.htm
DOI	http://dx.doi.org/10.5306/wjco.v8.i3.190

Full Article (PDF)	WJCO-8-190.pdf
Full Article (Word)	WJCO-8-190.doc
Manuscript File	32703-Review.doc
Answering Reviewers	32703-Answering reviewers.pdf
Audio Core Tip	32703-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	32703-Conflict-of-interest statement.pdf
Copyright License Agreement	32703-Copyright assignment.pdf
Peer-review Report	32703-Peer-review(s).pdf
Scientific Misconduct Check	32703-Scientific misconduct check.pdf
Scientific Editor Work List	32703-Scientific editor work list.pdf