Publication Name	World Journal of Clinical Cases
Manuscript ID	33387
Country	India

Received	2017-02-06 08:48
Peer-Review Started	2017-02-07 09:41
To Make the First Decision	2017-04-17 09:14
Return for Revision	2017-04-18 14:56
Revised	2017-05-03 01:30
Second Decision	2017-05-11 13:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-05-19 05:38
Articles in Press	2017-05-19 05:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-08-08 07:21
Publish the Manuscript Online	2017-08-16 04:11

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Editorial
Article Title	Adjuvants to local anesthetics: Current understanding and future trends
Manuscript Source	Invited Manuscript
All Author List	Amlan Swain, Deb Sanjay Nag, Seelora Sahu and Devi Prasad Samaddar
Funding Agency and Grant Number
Corresponding Author	Dr. Deb Sanjay Nag, Department of Anaesthesia and Critical Care, Tata Main Hospital, C Road West, Northern Town, Bistupur, Jamshedpur 831011, India. ds.nag@tatasteel.com
Key Words	Local anesthetics; Adjuvants; Neurotoxicity; Opioids; Ketamine; Midazolam; Alpha-2 adrenoreceptor antagonists
Core Tip	The use of local anaesthetics in acute and chronic pain is limited by its duration of action and the dose dependent adverse effects. Adjuvants or additives are often used with local anaesthetics for its synergistic effect by prolonging the duration of sensory-motor block and limiting its cumulative dose requirement. Various drugs like opioids, epinephrine, alpha-2 ad­renergic antagonists, steroids, anti-inflammatory drugs, midazolam, ketamine, magnesium sulfate and neostigmine have been used to potentiate the effect of local anesthetics. Due its potential adverse effects, current research is exploring newer drugs and delivery mechanisms to prolong the duration of action of local anesthetics.
Publish Date	2017-08-16 04:11
Citation	Swain A, Nag DS, Sahu S, Samaddar DP. Adjuvants to local anesthetics: Current understanding and future trends. World J Clin Cases 2017; 5(8): 307-323
URL	http://www.wjgnet.com/2307-8960/full/v5/i8/307.htm
DOI	http://dx.doi.org/10.12998/wjcc.v5.i8.307

Full Article (PDF)	WJCC-5-307.pdf
Full Article (Word)	WJCC-5-307.doc
Manuscript File	33387-Review.docx
Answering Reviewers	33387-Answering reviewers.pdf
Audio Core Tip	33387-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	33387-Conflict-of-interest statement.pdf
Copyright License Agreement	33387-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20170205214222.pdf
Peer-review Report	33387-Peer-review(s).pdf
Scientific Misconduct Check	33387-Scientific misconduct check.pdf
Scientific Editor Work List	33387-Scientific editor work list.pdf