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9/14/2017 3:13:08 AM | Browse: 32 | Download: 24
Publication Name World Journal of Gastroenterology
Manuscript ID 33850
Country of Manuscript Source China
Received
2017-03-08 10:09
Peer-Review Started
2017-03-09 10:01
To Make the First Decision
2017-04-21 09:35
Return for Revision
2017-04-24 16:19
Revised
2017-05-02 01:24
Second Decision
2017-05-27 01:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-06-01 07:00
Articles in Press
2017-06-01 07:00
Publication Fee Transferred
2017-06-07 03:47
Edit the Manuscript by Language Editor
2017-07-09 02:52
Typeset the Manuscript
2017-08-29 08:24
Publish the Manuscript Online
2017-09-14 03:13
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non- commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Changes of Ghrelin/GOAT axis and mTOR pathway in the hypothalamus after sleeve gastrectomy in obese type-2 diabetes rats
Manuscript Source Unsolicited Manuscript
All Author List Qiang Wang, Wei Tang, Wen-Sheng Rao, Xin Song, Cheng-Xiang Shan and Wei Zhang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81270969 (to Zhang Wei)
National Natural Science Foundation of China 81300723 (to Shan Cheng-Xiang)
Shanghai Science and Technology Commission Foundation 12ZR1439100 (to Zhang Wei)
Correspondence To Zhang Wei, Professor, Department of General Surgery, Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Shanghai 200003, China. zhangwei412@aliyun.com
Keywords Ghrelin; Ghrelin O-acyltransferase; Type-2 Diabetes; Hypothalamus; Obesity; Sleeve gastrectomy; Mammalian target of rapamycin
Core Tip Recent studies have demonstrated a complex relationship between ghrelin, ghrelin O-acyltransferase (GOAT) and the mammalian target of rapamycin (mTOR) pathway. In our study, we examined the changes of the ghrelin/GOAT axis and the mTOR pathway in the hypothalamus after sleeve gastrectomy (SG). The mRNA and protein levels of ghrelin and GOAT decreased after SG, while NPY mRNA expression did not change. We also found that SG increased the protein levels of p-Akt, p-mTOR and p-S6. The reduction of ghrelin expression and activation of the mTOR pathway might have opposite effects on food intake. These findings might explain the weight, glucose and food intake regain after SG.
Publish Date 2017-09-14 03:13
Citation Wang Q, Tang W, Rao WS, Song X, Shan CX, Zhang W. Changes of Ghrelin/GOAT axis and mTOR pathway in the hypothalamus after sleeve gastrectomy in obese type-2 diabetes rats. World J Gastroenterol 2017; 23(34): 6231-6241
Url http://www.wjgnet.com/1007-9327/full/v23/i34/6231.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i34.6231
Full Article (PDF) WJG-23-6231.pdf
Full Article (Word) WJG-23-6231.doc
Revised Manuscript 33850-Review.docx
Peer-review Report 33850-Peer-review(s).pdf
Answering Reviewers 33850-Answering reviewers.pdf
Scientific Misconduct Check 33850-Scientific misconduct check.pdf
Scientific Editor Work List 33850-Scientific editor work list.pdf
Audio Core Tip 33850-Audio core tip.mp3
Biostatistics Review Certificate 33850-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 33850-Conflict-of-interest statement.pdf
Copyright License Agreement 33850-Copyright assignment.pdf
Data Sharing Statement 33850-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 33850-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 33850-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 33850-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 33850-Language certificate.pdf
Scientific Research Process 33850-Scientific research process.pdf