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9/14/2017 3:13:08 AM | Browse: 119 | Download: 149
Publication Name World Journal of Gastroenterology
Manuscript ID 34562
Country of Manuscript Source China
2017-05-08 09:14
Peer-Review Started
2017-05-08 16:46
To Make the First Decision
2017-06-22 01:02
Return for Revision
2017-06-23 09:11
2017-07-05 16:17
Second Decision
2017-08-01 02:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-08-08 17:02
Articles in Press
2017-08-08 17:02
Publication Fee Transferred
2017-08-10 14:54
Edit the Manuscript by Language Editor
2017-08-21 00:44
Typeset the Manuscript
2017-09-04 11:44
Publish the Manuscript Online
2017-09-14 03:13
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected b-y an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is prope-rly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Chemistry, Medicinal
Manuscript Type Basic Study
Article Title Dihydromyricetin-mediated inhibition of the Notch1 pathway induces apoptosis in QGY7701 and HepG2 hepatoma cells
Manuscript Source Unsolicited Manuscript
All Author List Cai-Jie Lu, Yi-Feng He, Wei-Zhuang Yuan, Li-Jun Xiang, Jian Zhang, Yan-Rui Liang, Juan Duan, Yun-He He and Ming-Yi Li
Author ORCID Number
Cai-Jie Lu http://orcid.org/0000-0003-2718-2767
Yi-Feng He http://orcid.org/0000-0001-7130-0308
Wei-Zhuang Yuan http://orcid.org/0000-0002-0450-4690
Li-Jun Xiang http://orcid.org/0000-0001-5310-6245
Jian Zhang http://orcid.org/0000-0002-9318-0228
Yan-Rui Liang http://orcid.org/0000-0002-5094-3790
Juan Duan http://orcid.org/0000-0002-5454-3727
Yun-He He http://orcid.org/0000-0001-8222-2755
Ming-Yi Li http://orcid.org/0000-0001-6317-9368
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Funds 81041099
Natural Science Foundation of Guangdong Province S2011010003750
Correspondence To Ming-Yi Li, PhD, Professor, Laboratory of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, No. 57 South Renmin Road, Zhanjiang 524001, Guangdong Province, China. limingyi62@163.com
Keywords Dihydromyricetin; Apoptosis; Hepatocellular carcinoma; Notch1
Core Tip The novel findings of this study are that Notch1 is highly expressed in tumor cells with higher degrees of malignancy and proliferative activity, Notch1 is involved in the development of hepatocellular carcinoma (HCC) and may serve as a potential diagnostic marker for HCC. Dihydromyricetin can strongly induce apoptosis of the hepatic cancer cell lines QGY7701 and HepG2 by downregulating the expression of Notch1.
Publish Date 2017-09-14 03:13
Citation Lu CJ, He YF, Yuan WZ, Xiang LJ, Zhang J, Liang YR, Duan J, He YH, Li MY. Dihydromyricetin-mediated inhibition of the Notch1 pathway induces apoptosis in QGY7701 and HepG2 hepatoma cells. World J Gastroenterol 2017; 23(34): 6242-6251
Url http://www.wjgnet.com/1007-9327/full/v23/i34/6242.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i34.6242
Full Article (PDF) WJG-23-6242.pdf
Full Article (Word) WJG-23-6242.doc
Revised Manuscript 34562-Review.docx
Peer-review Report 34562-Peer-review(s).pdf
Answering Reviewers 34562-Answering reviewers.pdf
Scientific Misconduct Check 34562-Scientific misconduct check.pdf
Scientific Editor Work List 34562-Scientific editor work listt.pdf
Audio Core Tip 34562-Audio core tip .mp3
Biostatistics Review Certificate 34562-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 34562-Conflict-of-interest statement.pdf
Copyright License Agreement 34562-Copyright assignment.pdf
Data Sharing Statement 34562-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 34562-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 34562-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 34562-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 34562-Language certificate.pdf
Scientific Research Process 34562-Scientific research process.pdf