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11/20/2017 4:03:35 AM | Browse: 669 | Download: 656
Publication Name World Journal of Gastroenterology
Manuscript ID 35170
Country/Territory China
Received
2017-06-30 00:33
Peer-Review Started
2017-06-30 08:33
To Make the First Decision
2017-08-15 03:41
Return for Revision
2017-08-16 09:16
Revised
2017-09-13 14:34
Second Decision
2017-09-25 06:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-09-26 01:48
Articles in Press
2017-09-26 01:48
Publication Fee Transferred
2017-09-27 09:06
Edit the Manuscript by Language Editor
2017-11-01 02:53
Typeset the Manuscript
2017-11-16 01:04
Publish the Manuscript Online
2017-11-20 04:03
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Chitinase 3-like 1 secreted by peritumoral macrophages in esophageal squamous cell carcinoma is a favorable prognostic factor for survival
Manuscript Source Unsolicited Manuscript
All Author List Shan Xing, Xin Zheng, Tao Zeng, Mu-Sheng Zeng, Qian Zhong, Yue-Song Cao, Kai-Lu Pan, Chu Wei, Fan Hou and Wan-Li Liu
ORCID
Author(s) ORCID Number
Shan Xing http://orcid.org/0000-0001-6204-9035
Xin Zheng http://orcid.org/0000-0003-1489-7886
Tao Zeng http://orcid.org/0000-0002-6058-5747
Mu-Sheng Zeng http://orcid.org/0000-0002-5410-2366
Qian Zhong http://orcid.org/0000-0003-1071-6996
Yue-Song Cao http://orcid.org/0000-0002-9754-3946
Kai-Lu Pan http://orcid.org/0000-0002-7780-0191
Chu Wei http://orcid.org/0000-0002-7199-5442
Fan Hou http://orcid.org/0000-0002-5848-3354
Wan-Li Liu http://orcid.org/0000-0002-7467-760X
Funding Agency and Grant Number
Corresponding Author Wan-Li Liu, PhD, Professor, Research Scientist, Department of Clinical Laboratory, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, Guangdong Province, China. liuwl@sysucc.org.cn
Key Words Esophageal squamous cell carcinoma; Pro­gnostic biomarker; Chitinase 3-like 1; Macrophage; Esophageal squamous cell carcinoma
Core Tip The current staging system is inadequate for predicting post-treated survival. Our study first established a connection between pretreated chitinase 3-like 1 (CHI3L1) and patients with esophageal squamous cell car­cinoma (ESCC), and serum CHI3L1 was primarily secreted by ESCC-surrounded macrophages, suggesting that CHI3L1 was a simple and inexpensive prognostic factor. This simple, convenient serological testing allows for clinical application. In addition, in our study, the ESCC microenvironment, especially the secretion of IL - 6 by esophageal tumor cells, promotes the macrophage production of CHI3L1. These findings might help to identify high-risk patients for treatment decisions and to elucidate the mechanisms of ESCC.
Publish Date 2017-11-20 04:03
Citation Xing S, Zheng X, Zeng T, Zeng MS, Zhong Q, Cao YS, Pan KL, Wei C, Hou F, Liu WL. Chitinase 3-like 1 secreted by peritumoral macrophages in esophageal squamous cell carcinoma is a favorable prognostic factor for survival. World J Gastroenterol 2017; 23(43): 7693-7704
URL http://www.wjgnet.com/1007-9327/full/v23/i43/7693.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i43.7693
Full Article (PDF) WJG-23-7693.pdf
Full Article (Word) WJG-23-7693.doc
Manuscript File 35170-Review.doc
Answering Reviewers 35170-Answering reviewers.pdf
Audio Core Tip 35170-Audio core tip.mp3
Biostatistics Review Certificate 35170-Biostatistics statement.PDF
Conflict-of-Interest Disclosure Form 35170-Conflict-of-interest statement.pdf
Copyright License Agreement 35170-Copyright assignment.PDF
Data Sharing Statement 35170-Data sharing statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 35170-Institutional-Animal-Care-and-Use-Committee-Statement-revision.docx
Institutional Review Board Approval Form or Document 35170-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 35170-Non-Native-Speakers-of-English-revision.pdf
Scientific Research Process 35170-Scientific research process.pdf
Peer-review Report 35170-Peer-review(s).pdf
Scientific Misconduct Check 35170-Scientific misconduct check.pdf
Scientific Editor Work List 35170-Scientific editor work list.pdf