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Articles Published Processes
11/20/2017 4:03:35 AM | Browse: 1230 | Download: 2141
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Received |
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2017-06-30 00:33 |
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Peer-Review Started |
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2017-06-30 08:33 |
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To Make the First Decision |
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2017-08-15 03:41 |
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Return for Revision |
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2017-08-16 09:16 |
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Revised |
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2017-09-13 14:34 |
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Second Decision |
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2017-09-25 06:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-09-26 01:48 |
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Articles in Press |
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2017-09-26 01:48 |
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Publication Fee Transferred |
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2017-09-27 09:06 |
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Edit the Manuscript by Language Editor |
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2017-11-01 02:53 |
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Typeset the Manuscript |
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2017-11-16 01:04 |
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Publish the Manuscript Online |
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2017-11-20 04:03 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Chitinase 3-like 1 secreted by peritumoral macrophages in esophageal squamous cell carcinoma is a favorable prognostic factor for survival
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shan Xing, Xin Zheng, Tao Zeng, Mu-Sheng Zeng, Qian Zhong, Yue-Song Cao, Kai-Lu Pan, Chu Wei, Fan Hou and Wan-Li Liu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Wan-Li Liu, PhD, Professor, Research Scientist, Department of Clinical Laboratory, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, Guangdong Province, China. liuwl@sysucc.org.cn |
| Key Words |
Esophageal squamous cell carcinoma; Prognostic biomarker; Chitinase 3-like 1; Macrophage; Esophageal squamous cell carcinoma |
| Core Tip |
The current staging system is inadequate for predicting post-treated survival. Our study first established a connection between pretreated chitinase 3-like 1 (CHI3L1) and patients with esophageal squamous cell carcinoma (ESCC), and serum CHI3L1 was primarily secreted by ESCC-surrounded macrophages, suggesting that CHI3L1 was a simple and inexpensive prognostic factor. This simple, convenient serological testing allows for clinical application. In addition, in our study, the ESCC microenvironment, especially the secretion of IL - 6 by esophageal tumor cells, promotes the macrophage production of CHI3L1. These findings might help to identify high-risk patients for treatment decisions and to elucidate the mechanisms of ESCC. |
| Publish Date |
2017-11-20 04:03 |
| Citation |
Xing S, Zheng X, Zeng T, Zeng MS, Zhong Q, Cao YS, Pan KL, Wei C, Hou F, Liu WL. Chitinase 3-like 1 secreted by peritumoral macrophages in esophageal squamous cell carcinoma is a favorable prognostic factor for survival. World J Gastroenterol 2017; 23(43): 7693-7704 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i43/7693.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i43.7693 |
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