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Publication Name World Journal of Otorhinolaryngology
Manuscript ID 3546
Country/Territory Finland
Received
2013-05-05 17:23
Peer-Review Started
2013-05-05 20:15
To Make the First Decision
2013-06-24 10:25
Return for Revision
2013-07-04 13:52
Revised
2013-08-22 23:24
Second Decision
2013-10-17 13:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-10-18 07:14
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-11-06 15:25
Publish the Manuscript Online
2013-12-03 15:38
ISSN 2218-6247 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Otorhinolaryngology
Manuscript Type Review
Article Title Nanoparticle based inner ear therapy
Manuscript Source Invited Manuscript
All Author List Ilmari Pyykkö, Jing Zou, Ya Zhang, Weikai Zhang, Hao Feng and Paavo Kinnunen
Funding Agency and Grant Number
Funding Agency Grant Number
EU Nanoear Integrated Project NMP4-CT-2006-026556
EU NanoCI Collaborative Project FP7 281056
Corresponding Author Ilmari Pyykk? Department of otolaryngology Hearing and Balance Research Unit University of Tampere Teiskontie 35, M-building Room 318 Tampere 33520, Finland e-mail ilmari.pyykko@uta.fi
Key Words Synthetic vector; Gene delivery; shRNA delivery; Targeted cochlear therapy; Minimally invasive therapy
Core Tip Several novel, multifunctional nanoparticles have been developed, which are targetable to selected tissue, biodegradable, traceable in vivo, and equipped with controlled payload release. They can be used to transport therapeutic agents, such as drugs, genes, small interfering RNAs and growth factors into the inner ear. To visualise the targetability and accuracy of the delivery, the nanoparticles can be traced with magnetic resonance imaging. It is hoped that this technology will come to be used as an alternative carrier to viral vectors traditionally used in gene delivery, but without the severe adverse effect.
Publish Date 2013-12-03 15:38
Citation Pyykk? I, Zou J, ZhangY, Zhang W, Feng H, Kinnunen P. Nanoparticle based inner ear therapy. World J Otorhinolaryngol 2013; 3(4): 114-133
Url http://www.wjgnet.com/2218-6247/full/v3/i4/114.htm
DOI http://dx.doi.org/10.5319/wjo.v3.i4.114
Full Article (PDF) WJO-3-114.pdf
Manuscript File 3546-Review.docx
Answering Reviewers 3546-Answering reviewers.pdf
Copyright License Agreement 3546-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 3546-Language certificate.pdf
Peer-review Report 3546-Peer reviews.pdf
Scientific Editor Work List 3546-Scientific editor work list.doc