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Articles Published Processes
1/14/2018 5:07:58 AM | Browse: 788 | Download: 1304
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Received |
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2017-09-30 11:05 |
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Peer-Review Started |
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2017-10-01 05:34 |
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To Make the First Decision |
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2017-10-25 04:11 |
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Return for Revision |
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2017-10-25 08:52 |
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Revised |
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2017-11-06 14:31 |
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Second Decision |
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2017-11-21 11:56 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2017-11-21 18:41 |
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Articles in Press |
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2017-11-21 18:41 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-11-28 21:01 |
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Typeset the Manuscript |
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2018-01-08 07:30 |
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Publish the Manuscript Online |
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2018-01-14 05:07 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Basic Study |
| Article Title |
Transplantation of bone marrow-derived endothelial progenitor cells and hepatocyte stem cells from liver-fibrosis rats ameliorates liver fibrosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ling Lan, Ran Liu, Ling-Yun Qin, Peng Cheng, Bo-Wei Liu, Bing-Yong Zhang, Song-Ze Ding and Xiuling Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
30900598 |
| Basic and Advanced Technology Research Program of Henan Province |
142300410380 |
| Medical Science and Technology Project of Henan Province |
201303211 |
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| Corresponding Author |
Ling Lan, MD, PhD, Associate Professor, Department of Gastroenterology and Hepatology, the People’s Hospital of Zhengzhou University, the Henan Provicial People’s Hospital, 7 Weiwu Road, Zhengzhou 450003, Henan, China. lanling95@163.com |
| Key Words |
Bone marrow; Endothelial progenitor cells; Liver stem cell; Cell transplantation; Liver fibrosis |
| Core Tip |
In addition to liver regeneration, hepatic neovascularization and endothelial/sinusoidal remodeling are critical factors for the treatment of liver fibrosis. Bone marrow-derived endothelial progenitor cells (BM-EPCs) have shown to play a role in hepatic angiogenesis and be beneficial to liver fibrosis. However, BM-EPCs are all derived from healthy individuals in recent studies. Here we evaluated the feasibility to obtain normal BM-EPCs from rats with liver fibrosis, and the effectiveness of combined transplantation of BM-EPCs and bone marrow-derived hepatocyte stem cells for treating liver fibrosis in order to achieve the dual effects of hepatic neovascularization and liver regeneration. |
| Publish Date |
2018-01-14 05:07 |
| Citation |
Lan L, Liu R, Qin LY, Cheng P, Liu BW, Zhang BY, Ding SZ, Li XL. Transplantation of bone marrow-derived endothelial progenitor cells and hepatocyte stem cells from liver fibrosis rats ameliorates liver fibrosis. World J Gastroenterol 2018; 24(2): 237-247 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i2/237.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i2.237 |
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