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Articles Published Processes
3/13/2018 8:32:30 AM | Browse: 933 | Download: 1365
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Received |
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2017-12-08 06:31 |
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Peer-Review Started |
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2017-12-08 06:56 |
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To Make the First Decision |
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2017-12-20 07:37 |
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Return for Revision |
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2017-12-21 12:05 |
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Revised |
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2017-12-29 03:35 |
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Second Decision |
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2018-01-23 09:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-01-23 22:46 |
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Articles in Press |
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2018-01-23 22:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-02-01 03:41 |
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Typeset the Manuscript |
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2018-03-09 06:02 |
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Publish the Manuscript Online |
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2018-03-13 08:32 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Proteinase-activated receptor 2 promotes tumor cell proliferation and metastasis by inducing epithelialmesenchymal transition and predicts poor prognosis in hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Liang Sun, Pi-Bao Li, Yan-Fen Yao, Ai-Yuan Xiu, Zhi Peng, Yu-Huan Bai and Yan-Jing Gao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Jinan college innovation plan |
26010105081333 |
| Shandong social development plan |
26010104011343 |
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| Corresponding Author |
Yan-Jing Gao, PhD, Chief Doctor, Professor, Department of Gastroenterology, Qilu Hospital of Shandong University, No. 107 West Wenhua Road, Jinan 250012, Shandong Province, China. gaoyanjing@sdu.edu.cn |
| Key Words |
Hepatocellular carcinoma; Proteinase-activated receptor-2; Epithelial-mesenchymal transition |
| Core Tip |
The role of proteinase-activated receptor-2 (PAR2) in tumor progression especially metastasis of hepatocellular carcinoma and how is it be regulated is still unclear. In this study, we found that PAR2 was upregulated in hepatocellular carcinoma (HCC) tumor tissues and related with poor prognosis in HCC patients. In addition, we proved that PAR2 could not only promote the proliferation and metastasis ability of SMMC-7721 and HepG2 cells in vitro, but also promoted xenograft tumor growth and HCC cell liver metastasis in vivo. These effects were mediated by the activation of ERK, which further induced epithelial-mesenchymal transition of HCC cells. |
| Publish Date |
2018-03-13 08:32 |
| Citation |
Sun L, Li PB, Yao YF, Xiu AY, Peng Z, Bai YH, Gao YJ. Proteinase-activated receptor 2 promotes tumor cell proliferation and metastasis by inducing epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma. World J Gastroenterol 2018; 24(10): 1120-1133 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i10/1120.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i10.1120 |
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