| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Mucosa repair mechanisms of Tong-Xie-Yao-Fang mediated by CRH-R2 in murine, dextran sulfate sodium-induced colitis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shan-shan Gong, Shi-yi Wang, Yi-hong Fan, Qing-Qing Han, Bin Lv, Yi Xu, Xi Chen and Yao-Er He |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 81473506 |
| Natural Science Foundation of Zhejiang Province |
No. LY13H030011 |
| State Administration of Traditional Chinese |
No. 2013ZB050 |
| Natural Science Foundation of Zhejiang Province |
No.Y17H290033 |
| Department of zhejiang province to build funded projects |
No. WKJ-ZJ-1531 |
| Zhejiang TCM science and technology project |
No. 2016ZB047 |
| Zhejiang TCM science and technology project |
No. 2017ZA056 |
| Zhejiang TCM science and technology project |
No. 2018ZB046 |
|
| Corresponding Author |
Yi-hong Fan, MD, PhD, Associate Professor, Department of Gastroenterology, First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54, Youdian Road, Shangcheng District, Hangzhou 310006, Zhejiang, China. yhfansjr@163.com |
| Key Words |
Tong-Xie-Yao-Fang; Aqueous extracts; Corticotropin-releasing hormone receptor 2; Urocortin 2; Astressin 2B; Mucosal healing; Ulcerative colitis |
| Core Tip |
Mucosal healing is a desired therapeutic endpoint in the treatment of inflammatory bowel disease. However, it is difficult to treat inflammatory bowel disease thoroughly, and there are some adverse reactions. Studies have shown that corticotropin-releasing hormone (CRH)-receptor (R)2 can activate the inflammatory response of intestinal mucosa and exert an antiinflammatory effect. Our preliminary study found that Tong-Xie-Yao-Fang could reduce the expression of CRH-R1, increase CRH-R2, and participate in reconstruction of the intestinal barrier. The aim of this study was to explore the significance of CRH-R2 in the mucosal healing of dextran sulfate sodium-induced colitis and study the effect of Tong-Xie-Yao-Fang on CRH-R2 expression and regulation. |
| Publish Date |
2018-04-27 03:25 |
| Citation |
Gong SS, Fan YH, Wang SY, Han QQ, Lv B, Xu Y, Chen X, He YE. Mucosa repair mechanisms of Tong-Xie-Yao-Fang mediated by CRH-R2 in murine, dextran sulfate sodium-induced colitis. World J Gastroenterol 2018; 24(16): 1766-1778 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i16/1766.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i16.1766 |
