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4/19/2018 7:56:07 AM | Browse: 367 | Download: 417
Publication Name World Journal of Gastroenterology
Manuscript ID 38315
Country/Territory Japan
2018-02-14 04:34
Peer-Review Started
2018-02-14 09:07
To Make the First Decision
2018-03-08 01:15
Return for Revision
2018-03-09 06:05
2018-03-16 06:07
Second Decision
2018-03-22 08:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-03-25 16:39
Articles in Press
2018-03-25 16:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-04-18 06:04
Publish the Manuscript Online
2018-04-19 07:56
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Evaluation of safety for hepatectomy in a novel mouse model with nonalcoholic-steatohepatitis
Manuscript Source Unsolicited Manuscript
All Author List Yusuke Ozawa, Takafumi Tamura, Yohei Owada, Yoshio Shimizu, Akira Kemmochi, Katsuji Hisakura, Takashi Matsuzaka, Hitoshi Shimano, Hiroko Isoda and Nobuhiro Ohkohchi
Author(s) ORCID Number
Yusuke Ozawa http://orcid.org/0000-0002-5436-2272
Takafumi Tamura http://orcid.org/0000-0003-0396-2291
Yohei Owada http://orcid.org/0000-0003-4979-7236
Yoshio Shimizu http://orcid.org/0000-0003-1853-7386
Akira Kemmochi http://orcid.org/0000-0002-4970-3706
Katsuji Hisakura http://orcid.org/0000-0001-9256-7140
Takashi Matsuzaka http://orcid.org/0000-0002-5898-3463
Hitoshi Shimano http://orcid.org/0000-0002-5562-5572
Hiroko Isoda http://orcid.org/0000-0002-1399-9541
Nobuhiro Ohkohchi http://orcid.org/0000-0003-2779-1247
Funding Agency and Grant Number
Funding Agency Grant Number
Ministry of Education, Culture, Sports, Science, and Technology of Japan, KAKENHI 26861059
Ministry of Education, Culture, Sports, Science, and Technology of Japan, KAKENHI 16K10489
Corresponding author Nobuhiro Ohkohchi, MD, PhD, Professor, Surgeon, Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tennoudai 1-1-1, Tsukuba-shi 305-8575, ibaraki-ken, Japan. nokochi3@md.tsukuba.ac.jp
Key Words Hepatectomy; Liver regeneration; Residual liver; Liver proliferation; Nonalcoholic steatohepatitis
Core Tip We report whether the liver resection volume in the nonalcoholic steatohepatitis (NASH) model influences surgical outcome. The population of patients with NASH has been increasing. However, few animal models fully reflect both the histopathology and pathophysiology of NASH in humans. We established a novel experimental NASH model that exhibited the same characteristics as NASH in humans. This study elucidates the metabolism of the residual liver after a hepatectomy with NASH. Compared with normal liver, the residual NASH liver function is impaired, especially its regenerative ability. Therefore, a larger residual volume is required to maintain liver function in NASH liver after partial hepatectomy.
Publish Date 2018-04-19 07:56
Citation Ozawa Y, Tamura T, Owada Y, Shimizu Y, Kemmochi A, Hisakura K, Matsuzaka T, Shimano H, Isoda H, Ohkohchi N. Evaluation of safety for hepatectomy in a novel mouse model with nonalcoholic-steatohepatitis. World J Gastroenterol 2018; 24(15): 1622-1631
Url http://www.wjgnet.com/1007-9327/full/v24/i15/1622.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i15.1622
Full Article (PDF) WJG-24-1622.pdf
Full Article (Word) WJG-24-1622.doc
Manuscript File 38315-Review.docx
Answering Reviewers 38315-Answering reviewers.pdf
Audio Core Tip 38315-Audio core tip.mp3
Biostatistics Review Certificate 38315-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 38315-Conflict-of-interest statement.pdf
Copyright License Agreement 38315-Copyright License Agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 38315-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 38315-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 38315-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 38315-Language certificate.pdf
Peer-review Report 38315-Peer-review(s).pdf
Scientific Misconduct Check 38315-Scientific misconduct check.pdf
Scientific Editor Work List 38315-Scientific editor work list.pdf