Publication Name	World Journal of Gastroenterology
Manuscript ID	38667
Country	Taiwan

Received	2018-03-08 10:34
Peer-Review Started	2018-03-09 01:24
To Make the First Decision	2018-03-21 03:22
Return for Revision	2018-03-21 07:22
Revised	2018-03-29 00:41
Second Decision	2018-03-30 10:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-03-30 18:55
Articles in Press	2018-03-30 18:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-04-10 06:55
Publish the Manuscript Online	2018-04-11 08:28

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Hepatitis B virus pre-S/S variants in liver diseases
Manuscript Source	Invited Manuscript
All Author List	Bing-Fang Chen
ORCID	Author(s) ORCID Number Bing-Fang Chen http://orcid.org/0000-0002-3697-1533
Funding Agency and Grant Number	Funding Agency Grant Number National Science Council NSC 96-2320-B-030-004-MY3
Corresponding Author	Bing-Fang Chen, PhD, Professor, School of Medicine, Fu-Jen Catholic University, 510 Chung-Cheng Road, Hsin-Chuang Dist, New Taipei City 24205, Taiwan. nurs1018@mail.fju.edu.tw
Key Words	Hepatitis B virus; Pre-S/S mutant; Pre-S deletion; Splice variant; spPS1; Chronic hepatitis; Liver cirrhosis; Hepatocellular carcinoma
Core Tip	Naturally occurring hepatitis B virus (HBV) pre-S/S variants have been identified and associated with progressive liver diseases. In this review, the author discusses five pre-S/S variants: pre-S deletion, pre-S point mutation, pre-S1 splice variant, C-terminus S point mutation, and pre-S/S nonsense mutation. Their associations with HBV genotype and the possible pathogenesis of pre-S/S variants are also discussed. Different pre-S/S variants cause liver diseases through different mechanisms. Most cause the intracellular retention of HBV envelope proteins and induction of endoplasmic reticulum stress, resulting in liver diseases. The exact pathogenesis of pre-S/S variants requires further investigation.
Publish Date	2018-04-11 08:28
Citation	Chen BF. Hepatitis B virus pre-S/S variants in liver diseases. World J Gastroenterol 2018; 24(14): 1507-1520
URL	http://www.wjgnet.com/1007-9327/full/v24/i14/1507.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i14.1507

Full Article (PDF)	WJG-24-1507.pdf
Full Article (Word)	WJG-24-1507.doc
Manuscript File	38667-Review.docx
Answering Reviewers	38667-Answering reviewers.pdf
Audio Core Tip	38667-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	38667-Conflict-of-interest statement.pdf
Copyright License Agreement	38667-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	38667-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	38667-Language certificate.pdf
Peer-review Report	38667-Peer-review(s).pdf
Scientific Misconduct Check	38667-Scientific misconduct check.pdf
Scientific Editor Work List	38667-Scientific editor work list.pdf