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8/13/2018 7:45:11 AM | Browse: 699 | Download: 644
Publication Name World Journal of Gastroenterology
Manuscript ID 39208
Country/Territory Türkiye
Received
2018-04-10 02:17
Peer-Review Started
2018-04-10 07:12
To Make the First Decision
2018-05-09 04:10
Return for Revision
2018-05-16 09:48
Revised
2018-05-29 17:24
Second Decision
2018-06-25 09:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-06-25 19:16
Articles in Press
2018-06-25 19:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-08-08 03:07
Publish the Manuscript Online
2018-08-13 07:45
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Host genetic factors affecting hepatitis B infection outcomes: Insights from genome-wide association studies
Manuscript Source Unsolicited Manuscript
All Author List Izzet Mehmet Akcay, Seyma Katrinli, Kamil Ozdil, Gizem Dinler Doganay and Levent Doganay
ORCID
Author(s) ORCID Number
Izzet Mehmet Akcay http://orcid.org/0000-0001-6364-0062
Seyma Katrinli http://orcid.org/0000-0003-1575-8642
Kamil Ozdil http://orcid.org/0000-0003-2556-3064
Gizem Dinler Doganay http://orcid.org/0000-0002-3586-1287
Levent Doganay http://orcid.org/0000-0002-2263-6689
Funding Agency and Grant Number
Corresponding Author Levent Doganay, MD, Associate Professor, Doctor, Department of Gastroenterology and Hepatology, Umraniye Teaching and Research Hospital, Umraniye, Istanbul 34764, Türkiye. levent.doganay@saglik.gov.tr
Key Words Genome-wide association studies; Hepatitis B infection; Hepatocellular carcinoma; Cirrhosis; Antigen presentation; Immune response to hepatitis B virus
Core Tip Genome-wide association studies (GWAS) have proven to be very useful in uncovering the host gene­tic factors that influence the clinical outcomes of hepa­titis B virus (HBV) infection. Both class Ⅰ and class Ⅱ human leukocyte antigen (HLA) genes were implicated in persistence of HBV infection; associated variants affected antigen-binding specificities and expression levels of HLA molecules. HBV persistence and vaccine nonresponse were associated with the same HLA-DP allo­types, suggesting a critical role for the surface antigen in HBV pathogenesis. These findings might be exploited for development of potent vaccines based on alternative epitopes. GWAS for HBV-related pathologies identified many other immune-related genes, and provided genetic markers to detect the individuals at high risk for HBV-related diseases.
Publish Date 2018-08-13 07:45
Citation Akcay IM, Katrinli S, Ozdil K, Dinler Doganay G, Doganay L. Host genetic factors affecting hepatitis B infection outcomes: Insights from genome-wide association studies. World J Gastroenterol 2018; 24(30): 3347-3360
URL http://www.wjgnet.com/1007-9327/full/v24/i30/3347.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i30.3347
Full Article (PDF) WJG-24-3347.pdf
Manuscript File 39208-Review.docx
Answering Reviewers 39208-Answering reviewers.pdf
Audio Core Tip 39208-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 39208-Conflict-of-interest statement.pdf
Copyright License Agreement 39208-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 39208-Non-Native Speakers of English Editing Certificate.docx
Peer-review Report 39208-Peer-review(s).pdf
Scientific Misconduct Check 39208-Scientific misconduct check.pdf
Scientific Editor Work List 39208-Scientific editor work list.pdf