Publication Name	World Journal of Psychiatry
Manuscript ID	39213
Country	Nigeria

Received	2018-04-03 01:49
Peer-Review Started	2018-04-03 10:31
To Make the First Decision	2018-05-02 03:42
Return for Revision	2018-05-03 07:02
Revised	2018-05-06 19:57
Second Decision	2018-05-09 09:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-05-10 23:02
Articles in Press	2018-05-10 23:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-06-25 10:40
Publish the Manuscript Online	2018-06-28 10:44

ISSN	2220-3206 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Psychiatry
Manuscript Type	Review
Article Title	Melatonin in drug addiction and addiction management: Exploring an evolving multidimensional relationship
Manuscript Source	Invited Manuscript
All Author List	Olakunle J Onaolapo and Adejoke Y Onaolapo
ORCID	Author(s) ORCID Number Olakunle J Onaolapo http://orcid.org/0000-0003-2142-6046 Adejoke Y Onaolapo http://orcid.org/0000-0001-7126-7050
Funding Agency and Grant Number
Corresponding Author	Adejoke Y Onaolapo, MBBS, PhD, Behavioural Neuroscience/Neurobiology Unit, Department of Anatomy, Ladoke Akintola University of Technology, P.M.B 4000, Ogbomoso 210211, Oyo State, Nigeria. ayonaolapo@lautech.edu.ng
Key Words	Dopamine; Drug dependence; Biological rhythms; Neuroplasticity; Brain reward
Core Tip	Melatonin is a pleiotropic signalling molecule that regulates several physiological functions, and sy­nchronises biological rhythms. Recent evidences are beginning to reveal that a dysregulation of endogenous melatonin rhythm or action may play a larger role in the aetiology and behavioural expression of drug addiction, than was previously considered. This review, using inf­ormation garnered from extant literature, examines the roles played by melatonin and its receptors in add­ictive behaviours, addiction related changes in brain chemistry and brain plasticity; and its possible benefits in the management of drug associated withdrawal syn­drome, relapse and behavioural sensitisation.
Publish Date	2018-06-28 10:44
Citation	Onaolapo OJ, Onaolapo AY. Melatonin in drug addiction and addiction management: Exploring an evolving multidimensional relationship. World J Psychiatr 2018; 8(2): 64-74
URL	http://www.wjgnet.com/2220-3206/full/v8/i2/64.htm
DOI	http://dx.doi.org/10.5498/wjp.v8.i2.64

Full Article (PDF)	WJP-8-64.pdf
Full Article (Word)	WJP-8-64.doc
Manuscript File	39213-Review.docx
Answering Reviewers	39213-Answering reviewers.pdf
Audio Core Tip	39213-Audio core tip.wma
Conflict-of-Interest Disclosure Form	39213-Conflict-of-interest statement.pdf
Copyright License Agreement	39213-Copyright assignment.pdf
Peer-review Report	39213-Peer-review(s).pdf
Scientific Editor Work List	39213-Scientific editor work list.pdf