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11/27/2018 5:55:53 AM | Browse: 708 | Download: 822
Publication Name World Journal of Gastroenterology
Manuscript ID 40419
Country/Territory China
Received
2018-09-11 01:35
Peer-Review Started
2018-09-11 01:49
To Make the First Decision
2018-10-08 02:32
Return for Revision
2018-10-11 01:19
Revised
2018-10-20 13:46
Second Decision
2018-11-02 09:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-11-02 16:56
Articles in Press
2018-11-02 16:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-11-12 23:46
Typeset the Manuscript
2018-11-27 01:59
Publish the Manuscript Online
2018-11-27 05:55
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Development of a novel rat model of heterogeneous hepatic injury by injection with colchicine via the splenic vein
Manuscript Source Unsolicited Manuscript
All Author List Yan-Yan Zhang, Chao-Xu Zhang, Yu Li, Xuan Jiang, Yong-Fang Wang, Yang Sun, Jun Wang, Wan-Ying Ji and Yi Liu
ORCID
Author(s) ORCID Number
Yan-Yan Zhang http://orcid.org/0000-0003-4391-688X
Chao-Xu Zhang http://orcid.org/0000-0002-5643-2561
Yu Li http://orcid.org/0000-0002-4433-8420
Xuan Jiang http://orcid.org/0000-0002-3950-9504
Yong-Fang Wang http://orcid.org/0000-0002-4804-3566
Yang Sun http://orcid.org/0000-0001-7795-9824
Jun Wang http://orcid.org/0000-0003-4405-9867
Wan-Ying Ji http://orcid.org/0000-0002-9360-8642
Yi Liu http://orcid.org/0000-0002-3442-8713
Funding Agency and Grant Number
Corresponding Author Yi Liu, PhD, Professor, Department of Radiology, First Affiliated Hospital of China Medical University, Heping District, No. 155 Nanjing Street, Shenyang 110001, Liaoning Province, China. liuyicmu@sina.cn
Key Words Heterogeneous hepatic injury; Rat model; Colchicine; T2-weighted images; Diffusion weighted imaging
Core Tip In this study, injection with colchicine via the splenic vein is shown to successfully develop a rat model of heterogeneous hepatic injury. Obvious pathological changes occurred in the hepatic paren­chyma in the colchicine group. A significant difference was observed in liver injury scores, apparent diffusion coefficient values, and liver-to-muscle ratios of T2-weighted images (T2WI) between the left and right lobes in the colchicine group (P < 0.05). Our study suggested that diffusion weighted imaging and T2WI can be used to evaluate the heterogeneous injury among liver lobes.
Publish Date 2018-11-27 05:55
Citation Zhang YY, Zhang CX, Li Y, Jiang X, Wang YF, Sun Y, Wang J, Ji WY, Liu Y. Development of a novel rat model of heterogeneous hepatic injury by injection with colchicine via the splenic vein. World J Gastroenterol 2018; 24(44): 5005-5012
URL http://www.wjgnet.com/1007-9327/full/v24/i44/5005.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i44.5005
Full Article (PDF) WJG-24-5005.pdf
Full Article (Word) WJG-24-5005.doc
The ARRIVE Guidelines 40419-The ARRIVE guidelines.pdf
Manuscript File 40419-Review.docx
Answering Reviewers 40419-Answering reviewers.pdf
Audio Core Tip 40419-Audio core tip.wav
Biostatistics Review Certificate 40419-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 40419-Copyright license agreement.pdf
Copyright License Agreement 40419-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 40419-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 40419-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 40419-Language certificate.pdf
Supplementary Material 40419-Supplementary-Material-revision.docx
Peer-review Report 40419-Peer-review(s).pdf
Scientific Misconduct Check 40419-Scientific misconduct check.pdf
Scientific Editor Work List 40419-Scientific editor work list.pdf