Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	40829
Country	United Kingdom

Received	2018-07-10 00:57
Peer-Review Started	2018-07-10 04:57
To Make the First Decision	2018-08-03 00:16
Return for Revision	2018-08-03 07:25
Revised	2018-08-06 17:32
Second Decision	2018-09-12 10:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-10-09 21:03
Articles in Press	2018-10-09 21:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-10-24 09:19
Publish the Manuscript Online	2018-10-25 07:50

ISSN	2150-5349 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Challenges in the management of pancreatic exocrine insufficiency
Manuscript Source	Invited Manuscript
All Author List	Benjamin Myles Shandro, Rani Nagarajah and Andrew Poullis
ORCID	Author(s) ORCID Number Benjamin Myles Shandro http://orcid.org/0000-0003-2496-5301 Rani Nagarajah http://orcid.org/0000-0002-1668-2996 Andrew Poullis http://orcid.org/0000-0003-0703-0328
Funding Agency and Grant Number
Corresponding Author	Benjamin Myles Shandro, MBBS, MRCP, Doctor, Department of gastroenterology, St George's University Hospitals NHS Foundation Trust, Blackshaw Road, Tooting, London SW17 0QT, United Kingdom. bshandro@nhs.net
Key Words	Pancreatic exocrine insufficiency; Chronic pancreatitis; Steatorrhoea; Pancreatic function tests; Pancreatic enzyme replacement therapy
Core Tip	Pancreatic exocrine insufficiency (PEI) is common, and the prevalence is likely to increase in line with global trends in associated conditions (notably increasing age and diabetes mellitus). The classical symptom of steatorrhoea is a late presentation of PEI. The diagnosis should be considered far earlier, based on risk factors and clinical history. A current, prag­matic approach to diagnosis combines clinical history, assessment of nutritional status and measurement of faecal elastase-1. Treatment with pancreatic enzyme replacement therapy (PERT) is safe and effective. PERT must be adequately dosed, monitored, and optimized to ensure its benefits are realized.
Publish Date	2018-10-25 07:50
Citation	Shandro BM, Nagarajah R, Poullis A. Challenges in the management of pancreatic exocrine insufficiency. World J Gastrointest Pharmacol Ther 2018; 9(5): 39-46
URL	http://www.wjgnet.com/2150-5349/full/v9/i5/39.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v9.i5.39

Full Article (PDF)	WJGPT-9-39.pdf
Full Article (Word)	WJGPT-9-39.doc
Manuscript File	40829-Review.docx
Answering Reviewers	40829-Answering reviewers.pdf
Audio Core Tip	40829-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	40829-Conflict-of-interest statement.pdf
Copyright License Agreement	40829-Copyright license agreement.pdf
Peer-review Report	40829-Peer-review(s).pdf
Scientific Misconduct Check	40829-Scientific misconduct check.pdf
Scientific Editor Work List	40829-Scientific editor work list.pdf