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10/26/2018 11:38:21 AM | Browse: 258 | Download: 311
Publication Name World Journal of Gastroenterology
Manuscript ID 41039
Country/Territory China
2018-07-27 03:15
Peer-Review Started
2018-07-27 05:49
To Make the First Decision
2018-08-27 01:00
Return for Revision
2018-08-27 09:28
2018-09-02 13:08
Second Decision
2018-09-27 06:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-10-05 23:08
Articles in Press
2018-10-05 23:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-10-15 13:38
Typeset the Manuscript
2018-10-22 07:31
Publish the Manuscript Online
2018-10-26 11:38
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Recovery of natural killer cells is mainly in post-treatment period in chronic hepatitis C patients treated with sofosbuvir plus ledipasvir
Manuscript Source Invited Manuscript
All Author List Xiao-Xiao Wang, Bi-Fen Luo, Han-Ji Jiang, Xu Cong, Qian Jin, Dan-Li Ma, Lai Wei and Bo Feng
Author(s) ORCID Number
Xiao-Xiao Wang http://orcid.org/0000-0003-1654-7302
Bi-Fen Luo http://orcid.org/0000-0001-7166-278X
Han-Ji Jiang http://orcid.org/0000-0003-2118-0584
Xu Cong http://orcid.org/0000-0001-8922-7321
Qian Jin http://orcid.org/0000-0002-5213-8680
Dan-Li Ma http://orcid.org/0000-0002-0936-6792
Lai Wei http://orcid.org/0000-0003-2326-1257
Bo Feng http://orcid.org/0000-0001-5084-6715
Funding Agency and Grant Number
Funding Agency Grant Number
National S&T Major Projects for Infectious Diseases Control 2017ZX10302201-004-001
Corresponding author Bo Feng, PhD, Chief Doctor, Professor, Research Fellow, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Peking University People’s Hospital, No.11 Xizhimen South Street, Beijing 100044, China. fengbo@pkuph.edu.cn
Key Words Direct-acting antivirals therapy; Hepatitis C virus; Natural killer cells; Natural killer subsets
Core Tip In our study, we observed the dynamic changes of natural killer (NK) cell subsets, phenotypes and functional parameters during and after direct-acting antivirals (DAAs) treatment and investigated the effect of sofosbuvir/ledipasvir therapy on innate immunity in genotype 1b hepatitis C virus (HCV)-infected patients. We illustrated that NK cells of chronic hepatitis C patients can be affected by DAAs and phenotypes and function of NK cells recovered not at early stage but mainly after the end of sofosbuvir/ledipasvir treatment. These findings may provide an explanation for HCV reinfection or liver carcinogenesis after HCV elimination.
Publish Date 2018-10-26 11:38
Citation Wang XX, Luo BF, Jiang HJ, Cong X, Jin Q, Ma DL, Wei L, Feng B. Recovery of natural killer cells is mainly in post-treatment period in chronic hepatitis C patients treated with sofosbuvir plus ledipasvir. World J Gastroenterol 2018; 24(40): 4554-4564
Url http://www.wjgnet.com/1007-9327/full/v24/i40/4554.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i40.4554
Full Article (PDF) WJG-24-4554.pdf
Full Article (Word) WJG-24-4554.doc
Manuscript File 41039-Review.docx
Answering Reviewers 41039-Answering reviewers.pdf
Audio Core Tip 41039-Audio core tip.m4a
Biostatistics Review Certificate 41039-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 41039-Conflict-of-interest statement.pdf
Copyright License Agreement 41039-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 41039-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 41039-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 41039-Non-Native Speakers of English Editing Certificate.pdf
Peer-review Report 41039-Peer-review(s).pdf
Scientific Misconduct Check 41039-Scientific misconduct check.pdf
Scientific Editor Work List 41039-Scientific editor work list.pdf