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Articles Published Processes
10/26/2018 11:38:21 AM | Browse: 721 | Download: 1107
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Received |
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2018-07-27 03:15 |
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Peer-Review Started |
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2018-07-27 05:49 |
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To Make the First Decision |
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2018-08-27 01:00 |
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Return for Revision |
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2018-08-27 09:28 |
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Revised |
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2018-09-02 13:08 |
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Second Decision |
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2018-09-27 06:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2018-10-05 23:08 |
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Articles in Press |
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2018-10-05 23:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-10-15 13:38 |
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Typeset the Manuscript |
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2018-10-22 07:31 |
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Publish the Manuscript Online |
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2018-10-26 11:38 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Recovery of natural killer cells is mainly in post-treatment period in chronic hepatitis C patients treated with sofosbuvir plus ledipasvir
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Xiao-Xiao Wang, Bi-Fen Luo, Han-Ji Jiang, Xu Cong, Qian Jin, Dan-Li Ma, Lai Wei and Bo Feng |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National S&T Major Projects for Infectious Diseases Control |
2017ZX10302201-004-001 |
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| Corresponding Author |
Bo Feng, PhD, Chief Doctor, Professor, Research Fellow, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Peking University People’s Hospital, No.11 Xizhimen South Street, Beijing 100044, China. fengbo@pkuph.edu.cn |
| Key Words |
Direct-acting antivirals therapy; Hepatitis C virus; Natural killer cells; Natural killer subsets |
| Core Tip |
In our study, we observed the dynamic changes of natural killer (NK) cell subsets, phenotypes and functional parameters during and after direct-acting antivirals (DAAs) treatment and investigated the effect of sofosbuvir/ledipasvir therapy on innate immunity in genotype 1b hepatitis C virus (HCV)-infected patients. We illustrated that NK cells of chronic hepatitis C patients can be affected by DAAs and phenotypes and function of NK cells recovered not at early stage but mainly after the end of sofosbuvir/ledipasvir treatment. These findings may provide an explanation for HCV reinfection or liver carcinogenesis after HCV elimination. |
| Publish Date |
2018-10-26 11:38 |
| Citation |
Wang XX, Luo BF, Jiang HJ, Cong X, Jin Q, Ma DL, Wei L, Feng B. Recovery of natural killer cells is mainly in post-treatment period in chronic hepatitis C patients treated with sofosbuvir plus ledipasvir. World J Gastroenterol 2018; 24(40): 4554-4564 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i40/4554.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i40.4554 |
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