| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Impact of conditioning regimen on peripheral blood hematopoietic cell transplant
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Michael Burns, Anurag K Singh, Carrie C Hoefer, Yali Zhang, Paul K Wallace, George L Chen, Alexis Platek, Timothy B Winslow, Austin J Iovoli, Christopher Choi, Maureen Ross, Philip L McCarthy and Theresa Hahn |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NIH/NCI |
P30CA16056 |
|
| Corresponding Author |
Anurag K Singh, MD, Attending Doctor, Professor, Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, United States. anurag.singh@roswellpark.org |
| Key Words |
Total body radiation; Peripheral blood hematopoietic cell transplant; Total nucleated dose; Neutrophil engraftment; Graft-versus-host-disease |
| Core Tip |
This study investigated infused hematopoietic cell doses and their interaction with conditioning regimen intensity on outcomes after peripheral blood hematopoietic cell transplant (PBHCT). Our retrospective cohort included 247 patients receiving a first, T-replete, human leukocyte antigen-matched allogeneic PBHCT. Neutrophil engraftment was significantly faster after reduced intensity total body irradiation (TBI) based conditioning [reduced intensity conditioning (RIC) + TBI] and > 4 × 106 CD34+ cells/kg infused. Overall and progression-free survival was significantly better in patients with a RIC + TBI regimen and total nucleated cell dose > 8 × 108/kg. |
| Publish Date |
2019-02-22 04:33 |
| Citation |
Burns M, Singh AK, Hoefer CC, Zhang Y, Wallace PK, Chen GL, Platek A, Winslow TB, Iovoli AJ, Choi C, Ross M, McCarthy PL, Hahn T. Impact of conditioning regimen on peripheral blood hematopoietic cell transplant. World J Clin Oncol 2019; 10(2): 86-97 |
| URL |
https://www.wjgnet.com/2218-4333/full/v10/i2/86.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v10.i2.86 |
