Publication Name	World Journal of Stem Cells
Manuscript ID	41840
Country	Switzerland

Received	2018-08-30 06:08
Peer-Review Started	2018-08-30 08:38
To Make the First Decision	2018-10-17 01:51
Return for Revision	2018-10-17 06:52
Revised	2018-10-18 08:01
Second Decision	2018-10-23 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-10-23 21:59
Articles in Press	2018-10-23 21:59
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-10-30 21:19
Typeset the Manuscript	2018-11-20 13:55
Publish the Manuscript Online	2018-11-26 06:01

ISSN	1948-0210 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Minireviews
Article Title	Single-cell analysis of tumors: Creating new value for molecular biomarker discovery of cancer stem cells and tumor-infiltrating immune cells
Manuscript Source	Invited Manuscript
All Author List	Ramin Radpour and Farzad Forouharkhou
ORCID	Author(s) ORCID Number Ramin Radpour http://orcid.org/0000-0002-5632-7833 Farzad Forouharkhou http://orcid.org/0000-0002-6249-6115
Funding Agency and Grant Number
Corresponding Author	Ramin Radpour, MSc, PhD, Senior Researcher, Tumor Immunology, Department for BioMedical Research (DBMR), University of Bern, Murtenstrasse 35, Bern 3008, Switzerland. ramin.radpour@dbmr.unibe.ch
Key Words	Cancer cells; Cancer stem cells; Cancer biomarkers; Tumor-infiltrating lymphocytes; Single-cell analysis
Core Tip	Extensive heterogeneity in cancer cells ne­gatively influences treatment efficacy and survival of patients. The existing molecular methods for biomar­ker discovery of cancer cells and cancer stem cells are often unsuited to capture the heterogeneous nature of cell populations. Recent advances in single-cell based profiling approaches allowed the detection of molecular changes in individual cancer cells. Therefore, single-cell analysis is leading to build a complete landscape of cell types within tumor cells and facilitating the study of complex molecular heterogeneity in cancer cell po­pulations. This will improve the investigation of more specific biomarkers to identify and target cancer stem cells.
Publish Date	2018-11-26 06:01
Citation	Radpour R, Forouharkhou F. Single-cell analysis of tumor cells: Creating new value for molecular biomarker discovery of cancer stem cells. World J Stem Cells 2018; 10(11): 160-171
URL	http://www.wjgnet.com/1948-0210/full/v10/i11/160.htm
DOI	http://dx.doi.org/10.4252/wjsc.v10.i11.160

Full Article (PDF)	WJSC-10-160.pdf
Full Article (Word)	WJSC-10-160.doc
Manuscript File	41840-Review.docx
Answering Reviewers	41840-Answering reviewers.pdf
Audio Core Tip	41840-Audio core tipn.mp3
Conflict-of-Interest Disclosure Form	41840-Conflict-of-interest statement.pdf
Copyright License Agreement	41840-Copyright license agreement.pdf
Peer-review Report	41840-Peer-review(s).pdf
Scientific Misconduct Check	41840-Scientific misconduct check.pdf
Scientific Editor Work List	41840-Scientific editor work list.pdf