| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Usefulness of urinary trypsinogen-2 and trypsinogen activation peptide in acute pancreatitis: A multicenter study in Japan
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hiroaki Yasuda, Keisho Kataoka, Yoshifumi Takeyama, Kazunori Takeda, Tetsuhide Ito, Toshihiko Mayumi, Shuji Isaji, Tetsuya Mine, Motoji Kitagawa, Seiki Kiriyama, Junichi Sakagami, Atsushi Masamune, Kazuo Inui, Kenji Hirano, Ryukichi Akashi, Masamichi Yokoe, Yoshio Sogame, Kazuichi Okazaki, Chie Morioka, Yasuyuki Kihara, Shigeyuki Kawa, Masao Tanaka, Akira Andoh, Wataru Kimura, Isao Nishimori, Junji Furuse, Isao Yokota and Tooru Shimosegawa |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Hiroaki Yasuda, MD, PhD, Doctor, Doctor, Senior Lecturer, Department of Medicine, Division of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajii-cho Kawaramachi Hirokoji Kamigyo-ku, Kyoto 6028566, Japan. hiyasuda@koto.kpu-m.ac.jp |
| Key Words |
Acute pancreatitis; Trypsinogen activation peptide; Urinary trypsinogen-2 dipstick test |
| Core Tip |
A total of 94 patients with acute abdominal pain were enrolled from 17 medical institutions in Japan from April 2009 to December 2012. The trypsinogen-2 dipstick test was positive in 57 of 78 patients with acute pancreatitis (sensitivity, 73.1%) and in 6 of 16 patients with abdominal pain but without any evidence of acute pancreatitis (specificity, 62.5%). The levels of urinary trypsinogen-2 and trypsinogen activation peptide (TAP) were significantly higher in patients with extended extra-pancreatic inflammation as evaluated by CT Grade. Urinary trypsinogen-2 and TAP may be considered as additional markers to determine extra-pancreatic inflammation in acute pancreatitis. |
| Publish Date |
2019-01-07 10:39 |
| Citation |
Yasuda H, Kataoka L, Takeyama Y, Takeda K, Ito T, Mayumi T, Isaji S, Mine T, Kitagawa M, Kiriyama S, Sakagami J, Masamune A, Inui K, Hirano K, Akashi R, Yokoe M, Sogame Y, Okazaki K, Morioka C, Kihara Y, Kawa S, Tanaka M, Andoh A, Kimura W, Nishimori I, Furuse J, Yokota I, Shimosegawa T. Usefulness of urinary trypsinogen-2 and trypsinogen activation peptide in acute pancreatitis: A multicenter study in Japan. World J Gastroenterol 2019; 25(1): 107-117 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i1/107.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i1.107 |
