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Publication Name World Journal of Stem Cells
Manuscript ID 42912
Country Brazil
Received
2018-10-22 06:58
Peer-Review Started
2018-10-23 02:54
To Make the First Decision
2018-11-16 01:48
Return for Revision
2018-11-16 04:43
Revised
2018-12-05 13:31
Second Decision
2018-12-14 09:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-12-17 18:24
Articles in Press
2018-12-17 18:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-02-25 10:19
Publish the Manuscript Online
2019-02-26 03:18
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Neurosciences
Manuscript Type Basic Study
Article Title Triple-modal imaging of stem-cells labeled with multimodal nanoparticles, applied in a stroke model
Manuscript Source Unsolicited Manuscript
All Author List Helio Rodrigues da Silva, Javier Bustamante Mamani, Mariana Penteado Nucci, Leopoldo Penteado Nucci, Andrea Tiemi Kondo, Daianne Maciely Carvalho Fantacini, Lucas Eduardo Botelho de Souza, Virginia Picanço-Castro, Dimas Tadeu Maciely Covas, José Mauro Kutner, Fernando Anselmo de Oliveira, Nelson Hamerschlak and Lionel Fernel Gamarra
ORCID
Author(s) ORCID Number
Helio Rodrigues da Silva http://orcid.org/0000-0002-1173-745X
Javier Bustamante Mamani http://orcid.org/0000-0001-5038-0070
Mariana Penteado Nucci http://orcid.org/0000-0002-1502-9215
Leopoldo Penteado Nucci http://orcid.org/0000-0002-1234-5845
Andrea Tiemi Kondo http://orcid.org/0000-0002-4228-8503
Daianne Maciely Carvalho Fantacini http://orcid.org/0000-0003-2694-0132
Lucas Eduardo Botelho de Souza http://orcid.org/0000-0003-4254-7509
Virginia Picanço-Castro http://orcid.org/0000-0002-3914-0938
Dimas Tadeu Maciely Covas http://orcid.org/0000-0002-7364-2595
José Mauro Kutner http://orcid.org/0000-0003-3784-6731
Fernando Anselmo de Oliveira http://orcid.org/0000-0002-7226-1694
Nelson Hamerschlak http://orcid.org/0000-0002-5140-5310
Lionel Fernel Gamarra http://orcid.org/0000-0002-3910-0047
Funding Agency and Grant Number
Funding Agency Grant Number
Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPq-465259/2014-6
Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPq-400856/2016-6
São Paulo State Research Support Foundation 2014/50983-3
São Paulo State Research Support Foundation 2016/21470-3
Corresponding Author Lionel Fernel Gamarra, MSc, PhD, Academic Research, Associate Research Scientist, Postdoc, Professor, Reader in Health Technology Assessment, Research Scientist, Senior Researcher, Statistician, Group of nanobiotechnology of The Albert Einstein Hospital,, Hospital Israelita Albert Einstein, Avenida Albert Einstein, 627/701 – Morumbi, São Paulo 05651-901, Brazil. lionelgamarra7@gmail.com
Key Words Multimodal nanoparticles; Human bone marrow mesenchymal stem cells; Near-infrared fluorescence image; Magnetic resonance image; Bioluminescence; Stroke
Core Tip Multimodal imaging techniques provide morpho-functional information for studying pathological events following ischemia associated with new tracers. Molecular imaging innovations will contribute to the further understanding of stem cell transplantation, allowing an assessment of their therapeutic effects at the molecular scale. In this study, we evaluate the sensitivity of triple-modal imaging of human bone marrow mesenchymal stem cells labeled with multimodal nanoparticles (MNPs) to quantify the internalized iron load and cellular viability as well as the correlation of quantification results between the techniques. We demonstrate the importance of quantifying the MNP load internalized into cells via triple-image evaluation and the efficacy of signal detection in a stroke model.
Publish Date 2019-02-26 03:18
Citation da Silva HR, Mamani JB, Nucci MP, Nucci LP, Kondo AT, Fantacini DMC, de Souza LEB, Picanço-Castro V, Covas DT, Kutner JM, de Oliveira FA, Hamerschlak N, Gamarra LF. Triple-modal imaging of stem-cells labeled with multimodal nanoparticles, applied in a stroke model. World J Stem Cells 2019; 11(2): 100-123
URL https://www.wjgnet.com/1948-0210/full/v11/i2/100.htm
DOI https://dx.doi.org/10.4252/wjsc.v11.i2.100
Full Article (PDF) WJSC-11-100.pdf
Full Article (Word) WJSC-11-100.docx
Manuscript File 42912-Review.docx
Answering Reviewers 42912-Answering reviewers.pdf
Audio Core Tip 42912-Audio core tip.mp3
Biostatistics Review Certificate 42912-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 42912-Conflict-of-interest statement.pdf
Copyright License Agreement 42912-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 42912-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 42912-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 42912-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 42912-Language certificate.pdf
Video 42912-Video-revision.mp4
Peer-review Report 42912-Peer-review(s).pdf
Scientific Misconduct Check 42912-Scientific misconduct check.pdf
Scientific Editor Work List 42912-Scientific editor work list.pdf