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12/21/2018 10:07:19 AM | Browse: 375 | Download: 449
Publication Name World Journal of Gastroenterology
Manuscript ID 42953
Country/Territory China
2018-10-19 06:50
Peer-Review Started
2018-10-19 08:56
To Make the First Decision
2018-11-22 06:23
Return for Revision
2018-11-22 07:14
2018-11-27 05:14
Second Decision
2018-11-30 09:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-12-01 03:56
Articles in Press
2018-12-01 03:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-12-05 13:28
Typeset the Manuscript
2018-12-20 08:29
Publish the Manuscript Online
2018-12-21 10:07
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Hepatitis C: From inflammatory pathogenesis to anti-inflammatory/hepatoprotective therapy
Manuscript Source Unsolicited Manuscript
All Author List Hu Li, Meng-Hao Huang, JD Jiang and Zong-Gen Peng
Author(s) ORCID Number
Hu Li http://orcid.org/0000-0002-7609-9399
Meng-Hao Huang http://orcid.org/0000-0002-2389-8680
JD Jiang http://orcid.org/0000-0002-1138-2943
Zong-Gen Peng http://orcid.org/0000-0001-7662-6892
Funding Agency and Grant Number
Funding Agency Grant Number
CAMS Innovation Fund for Medical Sciences 2017-I2M-3-012
National Natural Science Foundation, China 81773788
National Natural Science Foundation, China 81621064
Ministry of Science and Technology, China 2018ZX09711001-003-010
Corresponding Author Zong-Gen Peng, PhD, Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Tiantan Xili, Beijing 100050, China. pengzonggen@imb.pumc.edu.cn
Key Words Hepatitis C virus infection; Liver disease; Inflammatory pathogenesis; Anti-inflammatory and hepatoprotective therapy
Core Tip Inflammatory responses triggered by hepatitis C virus (HCV) infection lead to severe progressive liver diseases. Some inflammatory cytokines and chemokines may serve as biomarkers for the disease progression and therapeutic effect in chronic hepatitis C (CHC) patients. The inflammatory pathogenesis in HCV-infected patients is complicated, including classic pathogen pattern recognition, inflammasome activation, intrahepatic inflammatory cascade response, and oxidative and endoplasmic reticulum stress. Direct-acting antivirals (DAAs) are not sufficient to block the uncontrolled inflammation and disease progression in severe CHC patients. Therefore, coupling with anti-inflammatory/hepatoprotective agents with anti-HCV effects is a promising therapeutic regimen for advanced HCV-infected patients during or after treatment with DAAs.
Publish Date 2018-12-21 10:07
Citation Li H, Huang MH, Jiang JD, Peng ZG. Hepatitis C: From inflammatory pathogenesis to anti-inflammatory/hepatoprotective therapy. World J Gastroenterol 2018; 24(47): 5297-5311
URL https://www.wjgnet.com/1007-9327/full/v24/i47/5297.htm
DOI https://dx.doi.org/10.3748/wjg.v24.i47.5297
Full Article (PDF) WJG-24-5297.pdf
Full Article (Word) WJG-24-5297.docx
Manuscript File 42953-Review.docx
Answering Reviewers 42953-Answering reviewers.pdf
Audio Core Tip 42953-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 42953-Conflict-of-interest statement.pdf
Copyright License Agreement 42953-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 42953-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 42953-Language certificate.pdf
Peer-review Report 42953-Peer-review(s).pdf
Scientific Misconduct Check 42953-Scientific misconduct check.pdf
Scientific Editor Work List 42953-Scientific editor work list.pdf