| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Alcoholic liver disease: Utility of animal models
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Arantza Lamas-Paz, Fengjie Hao, Leonard J Nelson, Maria Teresa Vazquez, Santiago Canals, Manuel Gomez del Moral, Eduardo Martínez-Naves, Yulia A. Nevzorova and Francisco Javier Cubero |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| MINECO Retos |
SAF2016-78711 and SAF2017-87919R |
| GILEAD |
44/2018 |
| Ramón y Cajal |
RYC-2014-15242 and RYC-2015-17438 |
| AMMF Cholangiocarcinoma Charity |
2018/117 |
| COST Action CA17112 |
CA17112 |
| Comunidad de Madrid |
EXOHEP-CM S2017/BMD-3727 |
| EXOHEP-CM |
S2017/BMD-3727 |
| grant of ERAB |
No. EA 14/18 |
| Ministerio de Sanidad, Servicios Sociales e Igualdad |
2017I065 |
| the UCM group “Lymphocyte Immunobiology” |
920631 |
|
| Corresponding Author |
Francisco Javier Cubero, BSc, MSc, PhD, Assistant Professor, Department of Immunology, Ophthalmology and ORL, Complutense University School of Medicine, c/Doctor Severo Ochoa 9, Madrid 28040, Spain. fcubero@ucm.es |
| Key Words |
Steatohepatitis; Cirrhosis; Hepatocellular carcinoma; Alcoholic liver disease; Reactive oxygen species |
| Core Tip |
Alcoholism is now considered a global health issue. Although significant progress has been made in our understanding of the mechanisms and pathology of alcoholic liver disease (ALD), many features of ALD remain unidentified - requiring further investigation with improved animal models that more effectively emulate human ALD. In this Review, we provide an update on the prevalence, current and emerging experimental models, as well as the pathophysiology of ALD. |
| Publish Date |
2018-12-07 03:57 |
| Citation |
Lamas-Paz A, Hao F, Nelson LJ, Vázquez MT, Canals S, Gómez del Moral M, Martínez-Naves E, Nevzorova YA, Cubero FJ. Alcoholic liver disease: Utility of animal models. World J Gastroenterol 2018; 24(45): 5063-5075 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i45/5063.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i45.5063 |
