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4/13/2019 6:00:06 AM | Browse: 18 | Download: 16
Publication Name World Journal of Gastroenterology
Manuscript ID 46017
Country of Manuscript Source China
Received
2019-01-30 01:50
Peer-Review Started
2019-01-31 01:23
To Make the First Decision
2019-02-26 07:36
Return for Revision
2019-02-27 00:29
Revised
2019-03-05 15:02
Second Decision
2019-03-15 09:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-03-16 17:53
Articles in Press
2019-03-16 17:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-03-25 14:11
Typeset the Manuscript
2019-04-04 06:46
Publish the Manuscript Online
2019-04-13 06:00
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Basic Study
Article Title Clinical significance of programmed death 1/programmed death ligand 1 pathway in gastric neuroendocrine carcinomas
Manuscript Source Unsolicited Manuscript
All Author List Min-Wei Yang, Xue-Liang Fu, Yong-Sheng Jiang, Xiao-Jing Chen, Ling-Ye Tao, Jian-Yu Yang, Yan-Miao Huo, Wei Liu, Jun-Feng Zhang, Pei-Feng Liu, Qiang Liu, Rong Hua, Zhi-Gang Zhang, Yong-Wei Sun and De-Jun Liu
ORCID
Author(s) ORCID Number
Min-Wei Yang http://orcid.org/0000-0002-9902-2183
Xue-Liang Fu http://orcid.org/0000-0002-2454-207X
Yong-Sheng Jiang http://orcid.org/0000-0002-6073-284X
Xiao-Jing Chen http://orcid.org/0000-0002-0241-1968
Ling-Ye Tao http://orcid.org/0000-0001-8930-6302
Jian-Yu Yang http://orcid.org/0000-0002-4868-1437
Yan-Miao Huo http://orcid.org/0000-0003-4730-7184
Wei Liu http://orcid.org/0000-0001-7064-3798
Jun-Feng Zhang http://orcid.org/0000-0002-8630-3090
Pei-Feng Liu http://orcid.org/0000-0003-1391-0727
Qiang Liu http://orcid.org/0000-0002-8095-2049
Rong Hua http://orcid.org/0000-0003-2477-3764
Zhi-Gang Zhang http://orcid.org/0000-0001-8965-223X
Yong-Wei Sun http://orcid.org/0000-0002-5937-634X
De-Jun Liu http://orcid.org/0000-0001-5336-0809
Funding Agency and Grant Number
Funding Agency Grant Number
Municipal Commission of Health and Family Planning of Shanghai 20174Y0243
Cultivating Funds of Renji Hospital, School of Medicine, Shanghai Jiaotong University PYXJS 16-002
Municipal Commission of Health and Family Planning of Shanghai 20154Y0163
Correspondence To De-Jun Liu, MAMS, Doctor, Department of Biliary-Pancreatic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No 160 Pu Jian Road, Shanghai 200127, China. liudj1126@yeah.net
Keywords Programmed death 1; Programmed death ligand 1; Gastric neuroendocrine carcinomas; Prognosis; Tumor infiltrating lymphocytes
Core Tip This study for the first time demonstrated that programmed death ligand 1 (PD-L1) can be expressed by gastric neuroendocrine carcinomas (G-NECs) cancer cells and the high PD-L1 expression was associated with poor prognosis. And the high expression of PD-L1 may due to the copy number variant of PD-L1 gene or stimulation of tumor infiltrating lymphocytes. These findings provided important implications for the potential use of antibody therapies targeting the PD-1/PD-L1 signaling pathway in G-NECs.
Publish Date 2019-04-13 06:00
Citation Yang MW, Fu XL, Jiang YS, Chen XJ, Tao LY, Yang JY, Huo YM, Liu W, Zhang JF, Liu PF, Liu Q, Hua R, Zhang ZG, Sun YW, Liu DJ. Clinical significance of programmed death 1/programmed death ligand 1 pathway in gastric neuroendocrine carcinomas. World J Gastroenterol 2019; 25(14): 1684-1696
Url https://www.wjgnet.com/1007-9327/full/v25/i14/1684.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i14.1684
Full Article (PDF) WJG-25-1684.pdf
Full Article (Word) WJG-25-1684.docx
Manuscript File 46017-Review_Edited.doc
Answering Reviewers 46017-Answering reviewers.pdf
Audio Core Tip 46017-Audio core tip.mp3
Biostatistics Review Certificate 46017-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 46017-Conflict-of-interest statement.pdf
Copyright License Agreement 46017-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 46017-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 46017-Institutional review board statement.pdf
Peer-review Report 46017-Peer-review(s).pdf
Scientific Misconduct Check 46017-Scientific misconduct check.pdf
Scientific Editor Work List 46017-Scientific editor work list.pdf