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4/25/2019 3:13:57 AM | Browse: 941 | Download: 1077
Publication Name World Journal of Gastroenterology
Manuscript ID 46431
Country/Territory China
Received
2019-02-14 07:57
Peer-Review Started
2019-02-17 09:17
To Make the First Decision
2019-03-06 01:35
Return for Revision
2019-03-08 02:20
Revised
2019-03-12 15:09
Second Decision
2019-03-22 08:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-03-25 04:35
Articles in Press
2019-03-25 04:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-04-03 19:26
Typeset the Manuscript
2019-04-24 07:26
Publish the Manuscript Online
2019-04-25 03:13
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Immune response pattern varies with the natural history of chronic hepatitis B
Manuscript Source Unsolicited Manuscript
All Author List Wen-Tao Wang, Xue-Qi Zhao, Gui-Ping Li, Yi-Zhi Chen, Lin Wang, Mei-Fang Han, Wei-Na Li, Tao Chen, Guang Chen, Dong Xu, Qin Ning and Xi-Ping Zhao
ORCID
Author(s) ORCID Number
Wen-Tao Wang http://orcid.org/0000-0001-9605-9493
Xue-Qi Zhao http://orcid.org/0000-0002-9786-9639
Gui-Ping Li http://orcid.org/0000-0003-4579-1478
Yi-Zhi Chen http://orcid.org/0000-0003-3570-5951
Lin Wang http://orcid.org/0000-0002-1413-3918
Mei-Fang Han http://orcid.org/0000-0002-1948-8128
Wei-Na Li http://orcid.org/0000-0003-0211-9868
Tao Chen http://orcid.org/0000-0001-6590-7162
Guang Chen http://orcid.org/0000-0002-9964-373X
Dong Xu http://orcid.org/0000-0003-0199-6885
Qin Ning http://orcid.org/0000-0002-2027-9593
Xi-Ping Zhao http://orcid.org/0000-0003-2629-787X
Funding Agency and Grant Number
Funding Agency Grant Number
National Science Fund of China (NSFC) 30771911
National Science and Technology Major Project 2012ZX10002007-003
Corresponding Author Xi-Ping Zhao, MD, Professor, Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, Hubei Province, China. xpzhao@tjh.tjmu.edu.cn
Key Words Chronic hepatitis; Hepatitis B virus; Natural killer cells; Global-T cells; Virus-specific T cells; Natural history; heterogeneity
Core Tip Chronic hepatitis B is a highly heterogeneous disease, which can be divided into four phases: immune tolerant, immune active (IA), inactive carrier and hepatitis B envelope antigen (HBeAg)-negative hepatitis (ENEG). Natural killer (NK) and virus-specific T cells are two key effector cells of cellular immunity. Our study demonstrates the conversion of the immune response pattern along the natural history of chronic hepatitis B virus infection. NK cells were phenotypically activated in the clinical phases (IA and ENEG) with biochemical liver damage. NK, non-specific and virus-specific T cells were functionally impaired in immune tolerant and IA phases. With the spontaneous clearance of HBeAg and hepatitis B surface antigen decline, NK cell cytokine production and HBV-specific T cell responses were partially restored in the inactive carrier phase, and the ENEG phase was primarily dominated by nonantigen-specific T cell responses.
Publish Date 2019-04-25 03:13
Citation Wang WT, Zhao XQ, Li GP, Chen YZ, Wang L, Han MF, Li WN, Chen T, Chen G, Xu D, Ning Q, Zhao XP. Immune response pattern varies with the natural history of chronic hepatitis B. World J Gastroenterol 2019; 25(16): 1950-1963
URL https://www.wjgnet.com/1007-9327/full/v25/i16/1950.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i16.1950
Full Article (PDF) WJG-25-1950.pdf
Full Article (Word) WJG-25-1950.docx
Manuscript File FP6807_de5_CE1MS_KS-edit-46431.docx
Answering Reviewers 46431-Answering reviewers.pdf
Audio Core Tip 46431-Audio core tip.wav
Biostatistics Review Certificate 46431-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 46431-Conflict-of-interest statement.pdf
Copyright License Agreement 46431-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 46431-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 46431-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 46431-Language certificate.pdf
Peer-review Report 46431-Peer-review(s).pdf
Scientific Misconduct Check 46431-Scientific misconduct check.pdf
Scientific Editor Work List 46431-Scientific editor work list.pdf