ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Immune response pattern varies with the natural history of chronic hepatitis B
|
Manuscript Source |
Unsolicited Manuscript |
All Author List |
Wen-Tao Wang, Xue-Qi Zhao, Gui-Ping Li, Yi-Zhi Chen, Lin Wang, Mei-Fang Han, Wei-Na Li, Tao Chen, Guang Chen, Dong Xu, Qin Ning and Xi-Ping Zhao |
ORCID |
|
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Science Fund of China (NSFC) |
30771911 |
National Science and Technology Major Project |
2012ZX10002007-003 |
|
Corresponding Author |
Xi-Ping Zhao, MD, Professor, Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, Hubei Province, China. xpzhao@tjh.tjmu.edu.cn |
Key Words |
Chronic hepatitis; Hepatitis B virus; Natural killer cells; Global-T cells; Virus-specific T cells; Natural history; heterogeneity |
Core Tip |
Chronic hepatitis B is a highly heterogeneous disease, which can be divided into four phases: immune tolerant, immune active (IA), inactive carrier and hepatitis B envelope antigen (HBeAg)-negative hepatitis (ENEG). Natural killer (NK) and virus-specific T cells are two key effector cells of cellular immunity. Our study demonstrates the conversion of the immune response pattern along the natural history of chronic hepatitis B virus infection. NK cells were phenotypically activated in the clinical phases (IA and ENEG) with biochemical liver damage. NK, non-specific and virus-specific T cells were functionally impaired in immune tolerant and IA phases. With the spontaneous clearance of HBeAg and hepatitis B surface antigen decline, NK cell cytokine production and HBV-specific T cell responses were partially restored in the inactive carrier phase, and the ENEG phase was primarily dominated by nonantigen-specific T cell responses. |
Publish Date |
2019-04-25 03:13 |
Citation |
Wang WT, Zhao XQ, Li GP, Chen YZ, Wang L, Han MF, Li WN, Chen T, Chen G, Xu D, Ning Q, Zhao XP. Immune response pattern varies with the natural history of chronic hepatitis B. World J Gastroenterol 2019; 25(16): 1950-1963 |
URL |
https://www.wjgnet.com/1007-9327/full/v25/i16/1950.htm |
DOI |
https://dx.doi.org/10.3748/wjg.v25.i16.1950 |