Publication Name	World Journal of Stem Cells
Manuscript ID	46522
Country	China

Received	2019-02-16 14:14
Peer-Review Started	2019-02-18 02:38
To Make the First Decision	2019-04-16 07:30
Return for Revision	2019-05-09 03:55
Revised	2019-05-15 11:28
Second Decision	2019-07-23 06:31
Accepted by Journal Editor-in-Chief	2019-07-23 18:24
Accepted by Company Editor-in-Chief	2019-07-30 04:16
Articles in Press	2019-07-30 04:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-08-22 12:26
Publish the Manuscript Online	2019-08-26 10:16

ISSN	1948-0210 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Review
Article Title	Derivation and applications of human hepatocyte-like cells
Manuscript Source	Invited Manuscript
All Author List	Shuang Li, Shi-Qian Huang, Yong-Xu Zhao, Yu-Jie Ding, Dan-Jun Ma and Qiu-Rong Ding
ORCID	Author(s) ORCID Number Shuang Li http://orcid.org/0000-0003-3929-2752 Shi-Qian Huang http://orcid.org/0000-0003-3066-8864 Yong-Xu Zhao http://orcid.org/0000-0003-4668-8165 Yu-Jie Ding http://orcid.org/0000-0001-9134-6493 Dan-Jun Ma http://orcid.org/0000-0002-1555-6306 Qiu-Rong Ding http://orcid.org/0000-0001-9906-6787
Funding Agency and Grant Number	Funding Agency Grant Number National Key R&D Program of China 2017YFA0102800, 2017YFA0103700 Strategic Priority Research Program of the Chinese Academy of Sciences XDA16030402 Key Research Program of the Chinese Academy of Sciences ZDRW-ZS-2017-1, KFZD-SW-213 National Natural Science Foundation of China 31670829, 81600650 Dongguan University of Technology Innovation Team Startup KCYCXPT2016003 Dongguan University of Technology Faculty Star-up G200906-05 to D.M. National Youth 1000 Talents Program Q.D.
Corresponding Author	Qiu-Rong Ding, PhD, Professor, CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China. qrding@sibs.ac.cn
Key Words	Hepatocyte-like cells; Human pluripotent stem cells; Hepatic differentiation; Biomedical application; ;
Core Tip	Hepatocyte-like cells (HLCs) derived from human pluripotent stem cells (hPSCs) have a great application prospect as an unlimited supply of human hepatocytes in disease modeling, toxicity testing and drug discovery. In this review, we summarize the derivation of HLCs from hPSCs, and the limitations and optimization of current differentiation protocols. We also discuss progress in the application of HLCs, and reveal the exciting future of HLCs for use in the study of rare diseases, population genetics, and in vitro pharmacogenomics.
Publish Date	2019-08-26 10:16
Citation	Li S, Huang SQ, Zhao YX, Ding YJ, Ma DJ, Ding QR. Derivation and applications of human hepatocyte-like cells. World J Stem Cell 2019; 11(8):535-547
URL	https://www.wjgnet.com/1948-0210/full/v11/i8/535.htm
DOI	https://dx.doi.org/10.4252/wjsc.v11.i8.535

Full Article (PDF)	WJSC-11-535.pdf
Full Article (Word)	WJSC-11-535.docx
Manuscript File	46522-Review.docx
Answering Reviewers	46522-Answering reviewers.pdf
Audio Core Tip	46522-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	46522-Conflict-of-interest statement.pdf
Copyright License Agreement	46522-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	46522-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	46522-Language certificate.pdf
Peer-review Report	46522-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	46522-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	46522-Scientific misconduct check.pdf
Scientific Editor Work List	46522-Scientific editor work list.pdf