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8/26/2019 10:16:55 AM | Browse: 123 | Download: 82
Publication Name World Journal of Stem Cells
Manuscript ID 46522
Country/Territory China
Received
2019-02-16 14:14
Peer-Review Started
2019-02-18 02:38
To Make the First Decision
2019-04-16 07:30
Return for Revision
2019-05-09 03:55
Revised
2019-05-15 11:28
Second Decision
2019-07-23 06:31
Accepted by Journal Editor-in-Chief
2019-07-23 18:24
Accepted by Company Editor-in-Chief
2019-07-30 04:16
Articles in Press
2019-07-30 04:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-08-22 12:26
Publish the Manuscript Online
2019-08-26 10:16
ISSN 1948-0210 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Review
Article Title Derivation and applications of human hepatocyte-like cells
Manuscript Source Invited Manuscript
All Author List Shuang Li, Shi-Qian Huang, Yong-Xu Zhao, Yu-Jie Ding, Dan-Jun Ma and Qiu-Rong Ding
ORCID
Author(s) ORCID Number
Shuang Li http://orcid.org/0000-0003-3929-2752
Shi-Qian Huang http://orcid.org/0000-0003-3066-8864
Yong-Xu Zhao http://orcid.org/0000-0003-4668-8165
Yu-Jie Ding http://orcid.org/0000-0001-9134-6493
Dan-Jun Ma http://orcid.org/0000-0002-1555-6306
Qiu-Rong Ding http://orcid.org/0000-0001-9906-6787
Funding Agency and Grant Number
Funding Agency Grant Number
National Key R&D Program of China 2017YFA0102800, 2017YFA0103700
Strategic Priority Research Program of the Chinese Academy of Sciences XDA16030402
Key Research Program of the Chinese Academy of Sciences ZDRW-ZS-2017-1, KFZD-SW-213
National Natural Science Foundation of China 31670829, 81600650
Dongguan University of Technology Innovation Team Startup KCYCXPT2016003
Dongguan University of Technology Faculty Star-up G200906-05 to D.M.
National Youth 1000 Talents Program Q.D.
Corresponding author Qiu-Rong Ding, PhD, Professor, CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China. qrding@sibs.ac.cn
Keywords Hepatocyte-like cells; Human pluripotent stem cells; Hepatic differentiation; Biomedical application; ;
Core Tip Hepatocyte-like cells (HLCs) derived from human pluripotent stem cells (hPSCs) have a great application prospect as an unlimited supply of human hepatocytes in disease modeling, toxicity testing and drug discovery. In this review, we summarize the derivation of HLCs from hPSCs, and the limitations and optimization of current differentiation protocols. We also discuss progress in the application of HLCs, and reveal the exciting future of HLCs for use in the study of rare diseases, population genetics, and in vitro pharmacogenomics.
Publish Date 2019-08-26 10:16
Citation Li S, Huang SQ, Zhao YX, Ding YJ, Ma DJ, Ding QR. Derivation and applications of human hepatocyte-like cells. World J Stem Cell 2019; 11(8):535-547
Url https://www.wjgnet.com/1948-0210/full/v11/i8/535.htm
DOI https://dx.doi.org/10.4252/wjsc.v11.i8.535
Full Article (PDF) WJSC-11-535.pdf
Full Article (Word) WJSC-11-535.docx
Manuscript File 46522-Review.docx
Answering Reviewers 46522-Answering reviewers.pdf
Audio Core Tip 46522-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 46522-Conflict-of-interest statement.pdf
Copyright License Agreement 46522-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 46522-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 46522-Language certificate.pdf
Peer-review Report 46522-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 46522-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 46522-Scientific misconduct check.pdf
Scientific Editor Work List 46522-Scientific editor work list.pdf