| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019 Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Unmodified autologous stem cells at point of care for chronic myocardial infarction
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Alexander Haenel, Mohamad Ghosn, Tahereh Karimi, Jody Vykoukal, Dipan Shah, Miguel Valderrabano, Daryl G Schulz, Albert Raizner, Christoph Schmitz and Eckhard U Alt |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Alliance of Cardiovascular Researchers (New Orleans, LA 70102, United States) |
2013-AH-01 (to Haenel A) |
|
| Corresponding Author |
Eckhard U Alt, MD, PhD, Chairman, Professor, Heart and Vascular Institute, Department of Medicine, Tulane University, Health Science Center, 1340 Tulane Ave., New Orleans, LA 70112, United States. ealt@tulane.edu |
| Key Words |
Adipose tissue-derived regenerative cells; Chronic myocardial infarction; Heart failure; Stem cells; Translational medicine; Point of care cell therapy |
| Core Tip |
We report results derived from a feasibility study on pigs whose left anterior descending (LAD) artery was occluded for 180 min. Four weeks later, 18 106 fresh, uncultured, unmodified, autologous adipose-derived regenerative cells were retrogradely delivered into the balloon blocked LAD vein (control: delivery of saline). Another six weeks later, mean left ventricular mass (+29%; P < 0.001) and cardiac output (+37%; P = 0.002) had significantly increased after delivery of cells. The unique combination of the procedure used for isolating stem cells and the novel cell delivery route applied in the present study potentially opens new horizons for clinical therapy for chronic myocardial infarction. |
| Publish Date |
2019-10-22 07:13 |
| Citation |
Haenel A, Ghosn M, Karimi T, Vykoukal J, Shah D, Valderrabano M, Schulz DG, Raizner A, Schmitz C, Alt EU. Unmodified autologous stem cells at point of care for chronic myocardial infarction. World J Stem Cells 2019; 11(10):831-858 |
| URL |
https://www.wjgnet.com/1948-0210/full/v11/i10/831.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v11.i10.831 |
