Publication Name	World Journal of Clinical Cases
Manuscript ID	46690
Country	Romania

Received	2019-02-20 02:52
Peer-Review Started	2019-02-20 03:31
To Make the First Decision	2019-03-05 02:09
Return for Revision	2019-03-11 01:42
Revised	2019-04-07 12:10
Second Decision	2019-05-03 03:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-05-03 10:57
Articles in Press	2019-05-03 10:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-06-18 04:21
Publish the Manuscript Online	2019-06-26 06:21

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Review
Article Title	Biomarkers vs imaging in the early detection of hepatocellular carcinoma and prognosis
Manuscript Source	Invited Manuscript
All Author List	Lavinia Alice Balaceanu
ORCID	Author(s) ORCID Number Lavinia Alice Balaceanu http://orcid.org/0000-0003-0441-3905
Funding Agency and Grant Number
Corresponding Author	Lavinia Alice Balaceanu, PhD, Associate Professor, Department of Internal Medicine, Carol Davila University of Medicine and Pharmacy, Sf. Ioan Clinical Emergency Hospital, Soseaua Vitan-Barzesti No. 13, Bucharest 42122, Romania. alicebalaceanu@yahoo.com
Key Words	Hepatocellular carcinoma; Biomarkers; Imaging; Ultrasonography; Computed tomography; Magnetic resonance imaging
Core Tip	Hepatocellular carcinoma (HCC) is an important cause of morbidity and mortality worldwide. Current HCC screening and diagnostic guidelines are based on imaging techniquesultrasonography for screening, and dynamic contrast-enhanced computed tomography, magnetic resonance, and ultrasound for diagnosis. The use of biomarkers is promising but the diverse aetiology and complex pathophysiological mechanisms of HCC make it difficult to find an ideal combination. This review systematically summarizes the existing data on the role of biomarkers in early diagnosis and prognosis of HCC, to promote efforts to find alternatives to the imaging investigations which are expensive and not always accepted by patients.
Publish Date	2019-06-26 06:21
Citation	Balaceanu LA. Biomarkers vs imaging in the early detection of hepatocellular carcinoma and prognosis. World J Clin Cases 2019; 7(12): 1367-1382
URL	https://www.wjgnet.com/2307-8960/full/v7/i12/1367.htm
DOI	https://dx.doi.org/10.12998/wjcc.v7.i12.1367

Full Article (PDF)	WJCC-7-1367.pdf
Full Article (Word)	WJCC-7-1367.docx
Manuscript File	46690-Review.docx
Answering Reviewers	46690-Answering reviewers.pdf
Audio Core Tip	46690-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	46690-Conflict-of-interest statement.pdf
Copyright License Agreement	46690-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	46690-Language certificate.pdf
Peer-review Report	46690-Peer-review(s).pdf
Scientific Misconduct Check	46690-Scientific misconduct check.pdf
Scientific Editor Work List	46690-Scientific editor work list.pdf