| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kandy T Velázquez, Reilly T Enos, Jackie E Bader, Alexander T Sougiannis, Meredith S Carson, Ioulia Chatzistamou, James A Carson, Prakash S Nagarkatti, Mitzi Nagarkatti and E Angela Murphy |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NCI |
1R21CA191966 |
| NCCIH |
K99AT009206 |
|
| Corresponding Author |
E Angela Murphy, PhD, Associate Professor, Department of Pathology, Microbiology & Immunology, University of South Carolina-School of Medicine, 6439 Garners Ferry Rd, Columbia, SC 29209, United States. angela.murphy@uscmed.sc.edu |
| Key Words |
High-fat diet; Obesity; Non-alcoholic fatty liver disease; Gut microbiome; Endoplasmic reticulum stress; Inflammation |
| Core Tip |
This work describes how mice consuming a chronic high-fat diet can mimic the clinical characteristics of non-alcoholic fatty liver disease. We used histopathological, metabolic, and molecular approaches to establish that prolonged high-fat-diet feedings in mice may be used as a pre-clinical model to study long-term interventions involving steatosis, steatohepatitis, fibrosis, glucose disturbances, endoplasmic reticulum stress, and gut microbial dysbiosis. |
| Publish Date |
2019-08-24 03:38 |
| Citation |
Velázquez KT, Enos RT, Bader JE, Sougiannis AT, Carson MS, Chatzistamou I, Carson JA, Nagarkatti P, Nagarkatti M, Murphy EA. Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice. World J Hepatol 2019; 11(8): 619-637 |
| URL |
https://www.wjgnet.com/1948-5182/full/v11/i8/619.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v11.i8.619 |
