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9/7/2019 4:43:36 AM | Browse: 88 | Download: 114
Publication Name World Journal of Gastroenterology
Manuscript ID 47249
Country of Manuscript Source China
2019-03-12 02:05
Peer-Review Started
2019-03-12 03:33
To Make the First Decision
2019-03-27 03:34
Return for Revision
2019-03-28 01:54
2019-04-04 00:37
Second Decision
2019-05-17 09:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-05-18 12:46
Articles in Press
2019-05-18 12:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-05-23 00:30
Typeset the Manuscript
2019-09-04 03:20
Publish the Manuscript Online
2019-09-07 04:43
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Retrospective Cohort Study
Article Title Prognostic value of preoperative carcinoembryonic antigen/tumor size in rectal cancer
Manuscript Source Invited Manuscript
All Author List Du Cai, Zeng-Hong Huang, Hui-Chuan Yu, Xiao-Lin Wang, Liang-Liang Bai, Guan-Nan Tang, Shao-Yong Peng, Ying-Jie Li, Meijin Huang, Guang-Wen Cao, Jian-Ping Wang and Yan-Xin Luo
Author(s) ORCID Number
Du Cai http://orcid.org/0000-0002-8894-7973
Zeng-Hong Huang http://orcid.org/0000-0003-3625-315X
Hui-Chuan Yu http://orcid.org/0000-0001-8357-1615
Xiao-Lin Wang http://orcid.org/0000-0002-3911-6911
Liang-Liang Bai http://orcid.org/0000-0002-1547-7931
Guan-Nan Tang http://orcid.org/0000-0001-6063-189X
Shao-Yong Peng http://orcid.org/000-0002-5489-4869
Ying-Jie Li http://orcid.org/0000-0003-3386-0210
Meijin Huang http://orcid.org/0000-0002-5483-4591
Guang-Wen Cao http://orcid.org/0000-0002-8094-1278
Jian-Ping Wang http://orcid.org/0000-0003-4654-6722
Yan-Xin Luo http://orcid.org/0000-0002-5200-3997
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China No. 81472257, YL; No. 81502022, XW
National Basic Research Program of China (973 Program) No. 2015CB554001, JW
Natural Science Fund for Distinguished Young Scholars of Guangdong Province No. 2016A030306002, YL
Tip-top Scientific and Technical Innovative Youth Talents of Guangdong special support program No. 2015TQ01R454, YL
Natural Science Foundation of Guangdong Province No. 2016A030310222, HY
Science and Technology Program of Guangzhou No. 201506010099, YL; No. 2014Y2-00160, JW
Fundamental Research Funds for the Central Universities (Sun Yat-sen University) No. 2015ykzd10, YL; No. 16ykpy35, XW
Corresponding author Yan-Xin Luo, MA, MD, PhD, Associate Professor, Chief Doctor, Doctor, Surgical Oncologist, Department of Colorectal Surgery, Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital, Sun Yat-sen University, 26 Yuancun Erheng Road, Guangzhou 510655, Guangdong Province, China. luoyx25@mail.sysu.edu.cn
Keywords Carcinoembryonic antigen; Carcinoembryonic antigen/tumor size; Rectal cancer; Prognosis; Survival analysis;
Core Tip This is a retrospective study that sought to evaluate the prognostic value of carcinoembryonic antigen (CEA)/tumor size in rectal cancer, which may better reflect the tumor malignancy. Maximally selected rank statistics identified an optimal cutoff point of 2.429 ng/mL per cm for CEA/tumor size. Kaplan-Meier curves showed a significant reduction in the 5-year overall survival and disease free survival in the high CEA/tumor size group. Univariate and multivariate analyses identified CEA/tumor size as an independent prognostic factor for stage I to III rectal cancer.
Publish Date 2019-09-07 04:43
Citation Cai D, Huang ZH, Yu HC, Wang XL, Bai LL, Tang GN, Peng SY, Li YJ, Huang MJ, Cao GW, Wang JP, Luo YX. Prognostic value of preoperative carcinoembryonic antigen/tumor size in rectal cancer. World J Gastroenterol 2019; 25(33): 4945-4958
Url https://www.wjgnet.com/1007-9327/full/v25/i33/4945.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i33.4945
Full Article (PDF) WJG-25-4945.pdf
Full Article (Word) WJG-25-4945.docx
Manuscript File 47249-Review_Edited.docx
Answering Reviewers 47249-Answering reviewers.pdf
Audio Core Tip 47249-Audio core tip.mp3
Biostatistics Review Certificate 47249-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 47249-Conflict-of-interest statement.pdf
Copyright License Agreement 47249-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 47249-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 47249-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 47249-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 47249-Language certificate.pdf
Peer-review Report 47249-Peer-review(s).pdf
Scientific Misconduct Check 47249-Google-MA RY-1.png
Scientific Misconduct Check 47249-Google-MA RY-2.png
Scientific Misconduct Check 47249-Scientific misconduct check.pdf
Scientific Editor Work List 47249-Scientific editor work list.pdf