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9/6/2019 1:44:07 PM | Browse: 90 | Download: 287
Publication Name World Journal of Clinical Cases
Manuscript ID 47301
Country/Territory Italy
Received
2019-03-20 02:39
Peer-Review Started
2019-03-20 07:16
To Make the First Decision
2019-05-28 03:01
Return for Revision
2019-06-03 09:25
Revised
2019-07-12 10:55
Second Decision
2019-07-27 02:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-07-27 22:20
Articles in Press
2019-07-27 22:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-08-09 18:33
Typeset the Manuscript
2019-09-04 10:11
Publish the Manuscript Online
2019-09-06 13:44
ISSN 2307-8960 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Observational Study
Article Title Multiplex gene expression profile in inflamed mucosa of patients with Crohn’s disease ileal localization: A pilot study
Manuscript Source Invited Manuscript
All Author List Francesco Giudici, Letizia Lombardelli, Edda Russo, Tiziana Cavalli, Daniela Zambonin, Federica Logiodice, Ornela Kullolli, Lamberto Giusti, Tatiana Bargellini, Marilena Fazi, Livia Biancone, Stefano Scaringi, Ann Maria Clemente, Eloisa Perissi, Giovanni Delfino, Maria Gabriella Torcia, Ferdinando Ficari, Francesco Tonelli, Marie-Pierre Piccinni and Cecilia Malentacchi
ORCID
Author(s) ORCID Number
Francesco Giudici http://orcid.org/0000-0002-6879-5685
Letizia Lombardelli http://orcid.org/0000-0001-9986-0956
Edda Russo http://orcid.org/0000-0003-3141-1091
Tiziana Cavalli http://orcid.org/0000-0001-8673-7190
Daniela Zambonin http://orcid.org/0000-0001-8892-2445
Federica Logiodice http://orcid.org/0000-0002-3426-304X
Ornela Kullolli http://orcid.org/0000-0002-7744-4596
Lamberto Giusti http://orcid.org/0000-0002-9972-090X
Tatiana Bargellini http://orcid.org/0000-0002-5381-8813
Marilena Fazi http://orcid.org/0000-0003-1117-7461
Livia Biancone http://orcid.org/0000-0002-9056-1957
Stefano Scaringi http://orcid.org/0000-0002-6838-8318
Ann Maria Clemente http://orcid.org/0000-0003-0386-590X
Eloisa Perissi http://orcid.org/0000-0001-9089-9205
Giovanni Delfino http://orcid.org/0000-0002-5434-5923
Maria Gabriella Torcia http://orcid.org/0000-0003-4740-4646
Ferdinando Ficari http://orcid.org/0000-0003-2248-6243
Francesco Tonelli http://orcid.org/0000-0002-0527-9851
Marie-Pierre Piccinni http://orcid.org/0000-0003-1810-5209
Cecilia Malentacchi http://orcid.org/0000-0002-3315-1396
Funding Agency and Grant Number
Funding Agency Grant Number
MIUR - Ministry of Education, University and Research 2008X8NRH4_003
Fondazione Cassa di Risparmio di Firenze 2008.1581, 2009.1301
Corresponding author Edda Russo, PhD, Academic Research, Postdoctoral Fellow, Biologist, Department of Experimental and Clinical Medicine, University of Florence, Viale Pieraccini 6, Florence 50134, Tuscany, Italy. edda.russo@unifi.it
Keywords Crohn's disease; Ileum; Colon; Messenger ribonucleic acid; Th1/Th17; Microbiota; Inflammation
Core Tip Multiplex Gene Assay in specimens obtained from patients with ileal localization of Crohn’s disease (CD) allowed the simultaneous analysis of messenger ribonucleic acid levels for 24 genes, known to be involved in the inflammation processes of CD pathogenesis. The result showed that the expression of genes related to Th1 and Th17 immune response is strongly activated as well as the expression of genes deputized to interact with the commensal microbiota, such as DEFB4 and HAMP, which code for antimicrobial peptides.
Publish Date 2019-09-06 13:44
Citation Giudici F, Lombardelli L, Cavalli T, Russo E, Zambonin D, Logiodice F, Kullolli O, Giusti L, Bargellini T, Fazi M, Biancone L, Scaringi S, Clemente AM, Perissi E, Delfino G, Torcia MG, Ficari F, Tonelli F, Piccinni MP, Malentacchi C. Multiplex gene expression profile in inflamed mucosa of patients with Crohn’s disease ileal localization: A pilot study. World J Clin Cases 2019; 7(17):2463-2476
Url https://www.wjgnet.com/2307-8960/full/v7/i17/2463.htm
DOI https://dx.doi.org/10.12998/wjcc.v7.i17.2463
Full Article (PDF) WJCC-7-2463.pdf
Full Article (Word) WJCC-7-2463.docx
Manuscript File FP6948_ce16_CE1MS_edit2.docx
Answering Reviewers 47301-Answering reviewers.pdf
Audio Core Tip 47301-Audio core tip.mp3
Biostatistics Review Certificate 47301-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 47301-Conflict-of-interest statement.pdf
Copyright License Agreement 47301-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 47301-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 47301-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 47301-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 47301-Language certificate.pdf
Peer-review Report 47301-Peer-review(s).pdf
Scientific Misconduct Check 47301-Scientific misconduct check.pdf
Scientific Editor Work List 47301-Scientific editor work list.pdf