| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Multiplex gene expression profile in inflamed mucosa of patients with Crohn’s disease ileal localization: A pilot study
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Francesco Giudici, Letizia Lombardelli, Edda Russo, Tiziana Cavalli, Daniela Zambonin, Federica Logiodice, Ornela Kullolli, Lamberto Giusti, Tatiana Bargellini, Marilena Fazi, Livia Biancone, Stefano Scaringi, Ann Maria Clemente, Eloisa Perissi, Giovanni Delfino, Maria Gabriella Torcia, Ferdinando Ficari, Francesco Tonelli, Marie-Pierre Piccinni and Cecilia Malentacchi |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| MIUR - Ministry of Education, University and Research |
2008X8NRH4_003 |
| Fondazione Cassa di Risparmio di Firenze |
2008.1581, 2009.1301 |
|
| Corresponding Author |
Edda Russo, PhD, Academic Research, Postdoctoral Fellow, Department of Experimental and Clinical Medicine, University of Florence, Viale Pieraccini 6, Florence 50134, Tuscany, Italy. edda.russo@unifi.it |
| Key Words |
Crohn's disease; Ileum; Colon; Messenger ribonucleic acid; Th1/Th17; Microbiota; Inflammation |
| Core Tip |
Multiplex Gene Assay in specimens obtained from patients with ileal localization of Crohn’s disease (CD) allowed the simultaneous analysis of messenger ribonucleic acid levels for 24 genes, known to be involved in the inflammation processes of CD pathogenesis. The result showed that the expression of genes related to Th1 and Th17 immune response is strongly activated as well as the expression of genes deputized to interact with the commensal microbiota, such as DEFB4 and HAMP, which code for antimicrobial peptides. |
| Publish Date |
2019-09-06 13:44 |
| Citation |
Giudici F, Lombardelli L, Cavalli T, Russo E, Zambonin D, Logiodice F, Kullolli O, Giusti L, Bargellini T, Fazi M, Biancone L, Scaringi S, Clemente AM, Perissi E, Delfino G, Torcia MG, Ficari F, Tonelli F, Piccinni MP, Malentacchi C. Multiplex gene expression profile in inflamed mucosa of patients with Crohn’s disease ileal localization: A pilot study. World J Clin Cases 2019; 7(17):2463-2476 |
| URL |
https://www.wjgnet.com/2307-8960/full/v7/i17/2463.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v7.i17.2463 |
