| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Histologic features and genomic alterations of primary colorectal adenocarcinoma predict the growth patterns of liver metastasis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing-Bo Wu, Ali Lopez Sarmiento, Pierre-Olivier Fiset, Anthoula Lazaris, Stephanie Petrillo, Peter Metrakos and Zu-Hua Gao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Human Resources Development Program for the Outstanding Talents in the Fifth People’s Hospital of Shanghai, Fudan University |
2017WYRCJY09 |
| the Key Medical Speciality of The Fifth People’s Hospital of Shanghai, Fudan University |
2017WY202K08 |
|
| Corresponding Author |
Zu-Hua Gao, FRCPC, MD, PhD, Professor, Department of Pathology, McGill University and the Research Institute of McGill University Health Center, Room E04.1820, 1001 Decarie Boulevard, Montreal H4A 3J1, Quebec, Canada. zu-hua.gao@mcgill.ca |
| Key Words |
Colorectal carcinoma; Liver metastasis; Histologic growth pattern; Clinicopathological characteristics; Whole exome sequencing |
| Core Tip |
Different histological growth patterns (HGPs) of colorectal carcinoma (CRC) liver metastasis were associated with patient’s prognosis and response to antiangiogenic therapy. The aim of our study was to assess whether certain clinicopathological and genomic features of primary CRC could predict the HGPs of liver metastasis. We found that the HGPs, tumor budding score (TBS), Crohn’s disease-like response (CDR) of primary CRC and the presence of specific genetic mutations such as PIK3CA could be used to predict the histological growth patterns of liver metastasis, response to therapy and patient’s prognosis. |
| Publish Date |
2019-07-14 11:25 |
| Citation |
Wu JB, Sarmiento AL, Fiset PO, Lazaris A, Petrillo S, Metrakos P, Gao ZH. Histologic features and genomic alterations of primary colorectal adenocarcinoma predict the growth patterns of liver metastasis. World J Gastroenterol 2019; 25(26): 3408-3425 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i26/3408.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i26.3408 |
