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8/7/2019 7:09:17 AM | Browse: 391 | Download: 388
Publication Name World Journal of Gastroenterology
Manuscript ID 47507
Country/Territory Italy
2019-03-17 09:21
Peer-Review Started
2019-03-18 08:48
To Make the First Decision
2019-05-14 01:13
Return for Revision
2019-05-15 00:58
2019-05-23 14:03
Second Decision
2019-06-26 10:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-07-03 01:15
Articles in Press
2019-07-03 01:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-08-06 02:30
Publish the Manuscript Online
2019-08-07 07:09
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Pharmacogenetics of the systemic treatment in advanced hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Elena De Mattia, Erika Cecchin, Michela Guardascione, Luisa Foltran, Tania Di Raimo, Francesco Angelini, Mario Rosario D'Andrea and Giuseppe Toffoli
Author(s) ORCID Number
Elena De Mattia http://orcid.org/0000-0003-4948-8767
Erika Cecchin http://orcid.org/0000-0001-7517-7490
Michela Guardascione http://orcid.org/0000-0001-5052-3502
Luisa Foltran http://orcid.org/0000-0002-2313-2247
Tania Di Raimo http://orcid.org/0000-0002-2896-8211
Francesco Angelini http://orcid.org/0000-0002-0052-6956
Mario Rosario D'Andrea http://orcid.org/0000-0003-4585-7473
Giuseppe Toffoli http://orcid.org/0000-0002-5323-4762
Funding Agency and Grant Number
Funding Agency Grant Number
European Union’s Horizon 2020 Research and Innovation Programme 668353
Corresponding Author Elena De Mattia, PhD, Postdoc, Experimental and Clinical Pharmacology Unit, CRO Aviano National Cancer Institute, IRCCS, via F. Gallini 2, Aviano (PN) 33081, Italy., Aviano 33081, Pordenone, Italy. edemattia@cro.it
Key Words Hepatocellular carcinoma; Pharmacogenetics; Genetic markers; Sorafenib; Regorafenib; Immune checkpoint inhibitors
Core Tip Patients with advanced hepatocellular carcinoma (HCC) have few effective therapeutic options. Although multikinase inhibitors — such as sorafenib as first-line treatment and regorafenib in sorafenib progressors — show some overall survival benefit, unmet needs persist in the treatment of advanced HCC. Particularly, the identification of potential prognostic and predictive biomarkers for better stratifying and personalizing the treatment remains a challenge. Germ-line polymorphisms have been suggested to contribute significantly to inter-individual variability in HCC therapy outcome in terms of both toxicity and effectiveness, opening new avenues for pharmacogenetic investigation.
Publish Date 2019-08-07 07:09
Citation De Mattia E, Cecchin E, Guardascione M, Foltran L, Di Raimo T, Angelini F, D’Andrea M, Toffoli G. Pharmacogenetics of the systemic treatment in advanced hepatocellular carcinoma. World J Gastroenterol 2019; 25(29): 3870-3896
URL https://www.wjgnet.com/1007-9327/full/v25/i29/3870.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i29.3870
Full Article (PDF) WJG-25-3870.pdf
Full Article (Word) WJG-25-3870.docx
Manuscript File 47507-Review.docx
Answering Reviewers 47507-Answering reviewers.pdf
Audio Core Tip 47507-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 47507-Conflict-of-interest statement.pdf
Copyright License Agreement 47507-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 47507-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 47507-Language certificate.pdf
Peer-review Report 47507-Peer-review(s).pdf
Scientific Misconduct Check 47507-Scientific misconduct check.pdf
Scientific Editor Work List 47507-Scientific editor work list.pdf