| ISSN |
2220-3230 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Retrospective Study |
| Article Title |
Histopathological characteristics and causes of kidney graft failure in the current era of immunosuppression
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Sandesh Parajuli, Fahad Aziz, Neetika Garg, Sarah E Panzer, Emily Joachim, Brenda Muth, Maha Mohamed, Justin Blazel, Weixiong Zhong, Brad C Astor, Didier A Mandelbrot and Arjang Djamali |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Sandesh Parajuli, MBBS, MD, Assistant Professor, Doctor, Division of Nephrology, Department of Medicine, University of Wisconsin, 4175 UW Medical Foundation Centennial Building, 1685 Highland Avenue, Madison, WI 53717, United States. sparajuli@medicine.wisc.edu |
| Key Words |
Kidney biopsy; Acute rejection; Graft failure; Transplant glomerulopathy; Interstitial fibrosis and tubular atrophy; |
| Core Tip |
There have been significant improvements in early graft survival. However, long-term graft survival has only had modest improvement. Causes of “true” late kidney allograft failure remain unclear. In this study, we explored the causes of graft failure based on the various factors, which may allow providers to determine interventions to prevent poor outcomes. We found, acute rejection, mainly antibody-mediated rejection, was the most common cause of early graft failure. And transplant glomerulopathy was a common cause of late graft failure, which occurred mainly after 6-7 years post-transplant even surpassed acute rejection. |
| Publish Date |
2019-10-28 09:27 |
| Citation |
Parajuli S, Aziz F, Garg N, Panzer SE, Joachim E, Muth B, Mohamed M, Blazel J, Zhong W, Astor BC, Mandelbrot DA, Djamali A. Histopathological characteristics and causes of kidney graft failure in the current era of immunosuppression. World J Transplant 2019; 9(6):123-133 |
| URL |
https://www.wjgnet.com/2220-3230/full/v9/i6/123.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v9.i6.123 |
