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11/28/2019 10:38:52 AM | Browse: 16 | Download: 15
Publication Name World Journal of Gastroenterology
Manuscript ID 51086
Country of Manuscript Source China
Received
2019-08-30 07:33
Peer-Review Started
2019-08-30 07:33
To Make the First Decision
2019-10-14 09:09
Return for Revision
2019-10-16 09:22
Revised
2019-10-30 04:06
Second Decision
2019-11-12 10:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-11-13 01:49
Articles in Press
2019-11-13 01:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-11-24 23:31
Typeset the Manuscript
2019-11-27 03:40
Publish the Manuscript Online
2019-11-28 10:38
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Long noncoding RNA NALT1-induced gastric cancer invasion and metastasis via NOTCH signaling pathway
Manuscript Source Unsolicited Manuscript
All Author List Hai-Yan Piao, Shuai Guo, Yue Wang and Jun Zhang
ORCID
Author(s) ORCID Number
Hai-Yan Piao http://orcid.org/0000-0002-3039-5758
Shuai Guo http://orcid.org/0000-0002-7418-6915
Yue Wang http://orcid.org/0000-0003-4536-9904
Jun Zhang http://orcid.org/0000-0003-1739-6462
Funding Agency and Grant Number
Funding Agency Grant Number
Liaoning S&T Project 20180550971
Liaoning S&T Project 20170520447
CSCO-MERCK SERNO oncology research fund Y-MX2016-031
Corresponding author Jun Zhang, MD, Doctor, Gastric Cancer Department, LiaoNing Cancer Hospital & Institute, Xiaoheyan Road, Dadong District, Shenyang 110042, Liaoning, China. surgeonzhangjun@hotmail.com
Keywords Gastric cancer; Weighted gene coexpression network analysis; NALT1; NOTCH1; Cancer survival;
Core Tip TCGA and clinical data identified lncRNA NALT1 was associated with poor prognosis of gastric cancer (GC) and the possible mechanism was also studied. We downloaded the TCGA-STAD RNA-seq data and identified the differentially expressed lncRNAs. WGCNA was used to clarify the connection between modules and clinical information. We then chose lncRNA NALT1 as the hub-lncRNA of blue-module. NALT1 was overexpressed and promoted invasion and metastasis of GC. The over-expression of NALT1 was linked to poor prognosis in GC. The mechanism may be related to the regulation of NOTCH1 by NALT1 and its effect on the expression of NOTCH signaling pathway.
Publish Date 2019-11-28 10:38
Citation Piao HY, Guo S, Wang Y, Zhang J. Long noncoding RNA NALT1-induced gastric cancer invasion and metastasis via NOTCH signaling pathway. World J Gastroenterol 2019; 25(44): 6508-6526
Url https://www.wjgnet.com/1007-9327/full/v25/i44/6508.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i44.6508
Full Article (PDF) WJG-25-6508.pdf
Full Article (Word) WJG-25-6508.docx
Manuscript File 51086 Review-Filipodia.docx
Answering Reviewers 51086-Answering reviewers.pdf
Audio Core Tip 51086-Audio core tip.mp3
Biostatistics Review Certificate 51086-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 51086-Conflict-of-interest statement.pdf
Copyright License Agreement 51086-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 51086-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 51086-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 51086-Language certificate.pdf
Peer-review Report 51086-Peer-review(s).pdf
Scientific Misconduct Check 51086-Scientific misconduct check.pdf
Scientific Editor Work List 51086-Scientific editor work list.pdf