| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Construction of a risk score prognosis model based on hepatocellular carcinoma microenvironment
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Fa-Peng Zhang, Yi-Pei Huang, Wei-Xin Luo, Wan-Yu Deng, Chao-Qun Liu, Lei-Bo Xu and Chao Liu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81972255 |
| National Natural Science Foundation of China |
81772597 |
| National Natural Science Foundation of China |
81672412 |
| Guangdong Natural Science Foundation |
2017A030311002 |
| Guangdong Science and Technology Foundation |
2017A020215196 |
| Fundamental Research Funds for the Central Universities of Sun Yat-Sen University |
17ykpy44 |
| Science Foundation of Jiangxi |
20181BAB214002 |
| Education Department Science and Technology Foundation of Jiangxi |
GJJ170936 |
| Grant from Guangdong Science and Technology Department |
2017B030314026 |
|
| Corresponding Author |
Chao Liu, MD, PhD, Chairman, Director, Professor, Department of Biliary Pancreatic Surgery, SunYat-sen Memorial Hospital, Sun Yat-sen University, No. 107, Yanjiang Road West, Guangzhou 510120, Guangdong Province, China. liuchao3@mail.sysu.edu.cn |
| Key Words |
Hepatocellular carcinoma; Prognostic model; Immune related gene; Microenvironment; Risk score; Overall survival |
| Core Tip |
In this study, we constructed a risk score model based on Hepatocellular carcinoma (HCC) microenvironment that could predict the overall survival (OS) of HCC. It has a high sensitivity and specificity in predicting the OS, and further validated in the Gene Expression Omnibus and the International Cancer Genome Consortium dataset. In addition, the risk score model is associate with immunosuppressive environment and immune checkpoint expression, assisting clinicians in selecting personalized immunotherapy for HCC patients. |
| Publish Date |
2020-01-13 11:27 |
| Citation |
Zhang FP, Huang YP, Luo WX, Deng WY, Liu CQ, Xu LB, Liu C. Construction of a risk score prognosis model based on hepatocellular carcinoma microenvironment. World J Gastroenterol 2020; 26(2): 134-153 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i2/134.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i2.134 |
