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1/13/2020 11:27:12 AM | Browse: 147 | Download: 207
Publication Name World Journal of Gastroenterology
Manuscript ID 51680
Country/Territory China
Received
2019-09-30 09:36
Peer-Review Started
2019-09-30 09:37
To Make the First Decision
Return for Revision
2019-11-10 05:31
Revised
2019-11-23 14:11
Second Decision
2019-12-06 07:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-12-06 22:22
Articles in Press
2019-12-06 22:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-12-29 03:10
Typeset the Manuscript
2020-01-11 10:10
Publish the Manuscript Online
2020-01-13 11:27
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Construction of a risk score prognosis model based on hepatocellular carcinoma microenvironment
Manuscript Source Invited Manuscript
All Author List Fa-Peng Zhang, Yi-Pei Huang, Wei-Xin Luo, Wan-Yu Deng, Chao-Qun Liu, Lei-Bo Xu and Chao Liu
ORCID
Author(s) ORCID Number
Fa-Peng Zhang http://orcid.org/0000-0002-1361-5536
Yi-Pei Huang http://orcid.org/0000-0003-3098-9123
Wei-Xin Luo http://orcid.org/0000-0001-6804-2520
Wan-Yu Deng http://orcid.org/0000-0001-7789-3861
Chao-Qun Liu http://orcid.org/0000-0002-0491-573X
Lei-Bo Xu http://orcid.org/0000-0002-9236-5343
Chao Liu http://orcid.org/0000-0001-6659-4372
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81972255
National Natural Science Foundation of China 81772597
National Natural Science Foundation of China 81672412
Guangdong Natural Science Foundation 2017A030311002
Guangdong Science and Technology Foundation 2017A020215196
Fundamental Research Funds for the Central Universities of Sun Yat-Sen University 17ykpy44
Science Foundation of Jiangxi 20181BAB214002
Education Department Science and Technology Foundation of Jiangxi GJJ170936
Grant from Guangdong Science and Technology Department 2017B030314026
Corresponding author Chao Liu, MD, PhD, Chairman, Director, Professor, Department of Biliary Pancreatic Surgery, SunYat-sen Memorial Hospital, Sun Yat-sen University, No. 107, Yanjiang Road West, Guangzhou 510120, Guangdong Province, China. liuchao3@mail.sysu.edu.cn
Keywords Hepatocellular carcinoma; Prognostic model; Immune related gene; Microenvironment; Risk score; Overall survival
Core Tip In this study, we constructed a risk score model based on Hepatocellular carcinoma (HCC) microenvironment that could predict the overall survival (OS) of HCC. It has a high sensitivity and specificity in predicting the OS, and further validated in the Gene Expression Omnibus and the International Cancer Genome Consortium dataset. In addition, the risk score model is associate with immunosuppressive environment and immune checkpoint expression, assisting clinicians in selecting personalized immunotherapy for HCC patients.
Publish Date 2020-01-13 11:27
Citation Zhang FP, Huang YP, Luo WX, Deng WY, Liu CQ, Xu LB, Liu C. Construction of a risk score prognosis model based on hepatocellular carcinoma microenvironment. World J Gastroenterol 2020; 26(2): 134-153
Url https://www.wjgnet.com/1007-9327/full/v26/i2/134.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i2.134
Full Article (PDF) WJG-26-134.pdf
Full Article (Word) WJG-26-134.docx
Manuscript File 51680-Review-Ma JY.docx
Answering Reviewers 51680-Answering reviewers.pdf
Audio Core Tip 51680-Audio core tip.mp3
Biostatistics Review Certificate 51680-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 51680-Conflict-of-interest statement.pdf
Copyright License Agreement 51680-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 51680-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 51680-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 51680-Language certificate.pdf
Supplementary Material 51680-Supplementary material.pdf
Peer-review Report 51680-Peer-review(s).pdf
Scientific Misconduct Check 51680-Scientific misconduct check.pdf
Scientific Editor Work List 51680-Scientific editor work list.pdf